Medtronic, Inc.

Other

Robert Cushing Hamlen

Roger J Elgas

Robert F Gremel

Richard T Stone

Cynthia T Clague

Frank D Dorman

Timothy A Miller

Michael P Sullivan

Donald W Hegeman, Iii

Joseph E Poissant

Mary M Morris

Tommy Dean Bennett

Dennis D Elsberry

Edwin G Duffin

Lawrence J Mulligan

Chris C Christiansen

Douglas O Hankner

Wael Abo-Auda

An implantable heart monitor (IHM) implanted in a patient's body having electrogram (EGM) sense electrodes coupled with EGM sense circuitry to generate sense events upon detection of cardiac depolarizations and a blood pressure measurement transducer disposed in a heart chamber and coupled with blood pressure measurement circuitry operates to assess heart failure state as a function of mechanical pulsus alternans (MPA). MPA episodes are detected, and MPA characteristics of the MPA episode are used alone or as a group as a diagnostic marker of HF state. The MPA episode data set can be stored in memory associated with a time and date stamp. The MPA characteristics of each MPA data set in a series of MPA data sets collected over time can be compared or plotted to determine if a trend indicative of change in HF state is discernible.

Implantable medical device for assessing heart failure state from Mechanical Pulsus Alternans

A medical catheter comprising a proximal end having an opening for fluid containing a therapeutic drug, a distal end, the distal end defining at least one opening, and a porous portion covering the opening defined by the distal end. In one embodiment, the medical catheter comprises a proximal end having an opening for fluid containing a therapeutic drug, at least two distal ends. the proximal end connected to the two distal ends with a connector, the distal ends each defining at least, one opening, a diffuser covering the opening of each distal end, and a separate restrictor downstream of the connector and upstream of each distal end to provide substantially equal flow through each distal end. An additional restrictor can also be placed upstream of the connector. In another embodiment, a combination diffuser and restrictor covers the opening of each distal end.

Catheter for target specific drug delivery

A biological fluid transport device comprises a cutwater at the junction of at least two blood flow paths. The cutwater is substantially straight, substantially vertical, or both. At least one of the fluid paths may be tubular, and in some embodiments all of the fluid paths are tubular. The shear sensitive fluid may be, without limitation, blood, blood-based combinations, cell culture media, cell suspensions, proteins, and microcapsule suspensions. The device may be part of an extracorporeal circuit (e.g., blood during heart-lung bypass procedures or blood processing), but it need not be. Preferred embodiments of the device include, without limitation, kinetic pumps, mass transfer devices, filters, reservoirs, and heat exchangers.

Junction for shears sensitive biological fluid paths

Junction for shear sensitive biological fluid paths

A blood inlet manifold is provided for connection to a first end of a blood heat exchanger including a plurality of hollow conduits arranged in a bundle. A plurality of first ends of the conduits terminate adjacent the first end of the blood heat exchanger and a plurality of second ends of the conduits terminate adjacent a second end of the blood heat exchanger. The blood inlet manifold includes a blood inlet nozzle having an upstream segment and a downstream segment. The upstream segment is connectable to a tube for conveying blood. The blood inlet manifold further includes a generally conical wall member connected to the downstream segment of the blood inlet nozzle and connectable to the first end of the blood heat exchanger. The connection of the blood inlet manifold to the blood heat exchanger defines a chamber between the conical wall member and the first set of ends of the conduits. An interior of the downstream segment of the blood inlet nozzle opens into this chamber.

Inlet manifold for blood oxygenator apparatus

A blood outlet manifold is provided for a membrane-type blood oxygenator made of a plurality of micro-porous fibers. The fibers have first and second ends wound into a generally cylindrical bundle. The blood outlet manifold comprises a generally cylindrical vessel having a first annular wall dimensioned to snugly overly an exterior surface of the oxygenator fiber bundle. The vessel further has a flared portion including a second annular wall radially spaced from an end portion of the exterior surface of the oxygenator fiber bundle adjacent to the second ends of the fibers. An annular blood collection chamber is defined between the exterior surface of the oxygenator fiber bundle and the second annular wall for receiving blood flowing radially outwardly from around the fibers of the oxygenator fiber bundle. A seal is provided between the end portion of the oxygenator fiber bundle and the second annular wall. A blood outlet nozzle extends from the flared portion of the vessel and has a hollow interior communicating with the blood collection chamber.

Outlet manifold for blood oxygenator apparatus

A transition manifold is provided for use in association with the upper end of a generally cylindrical heat exchanger fiber bundle having a plurality of vertically extending conduits with open upper ends terminating in substantially co-planar fashion. The transition manifold is specially configured for redirecting blood flowing out of the upper end of the heat exchanger fiber bundle radially outwardly around the fibers of a concentric, surrounding oxygenator fiber bundle. The transition manifold includes a generally conical wall member defining a surface which extends at a relatively flat angle with respect to a plane perpendicular to a vertical central axis of the heat exchanger fiber bundle. The surface of the conical wall member diverges away from the upper end of the heat exchanger fiber bundle in a direction moving radially outwardly from the central axis. The transition manifold spreads the blood substantially uniformally around an upper portion of the generally cylindrical oxygenator fiber bundle while minimizing shear forces that traumatize blood cells and platelets and minimizing recirculations which can lead to clotting.

Transition manifold for blood oxygenator apparatus

Growing community of inventors

Saint Paul, MN, United States of America

Robert Cushing Hamlen