Respira Therapeutics, Inc.

Other

Abbott Vascular, Inc.

Robert Curtis

Martin J Donovan

Hugh Smyth

Zhen Xu

Revati Shreeniwas

Dan Deaton

James Hannon

Aileen Gibbons

Jeffry G Weers

Alain Romero

Adaani Frost

Pravin L Soni

Stephen Lermer

Wilmer L Sibbitt, Jr

Randy R Sibbitt

Novel dry powder compositions comprising and methods relating thereto are provided. The dry powder compositions comprise PDE5 inhibitors, such as vardenafil, or pharmaceutically acceptable salts or esters thereof. The dry powder compositions may optionally include an carrier/excipient. The concentration of active agent may be at least about 2% by weight. Methods of aerosolizing the dry powder compositions and using them to treat various diseases are also disclosed.

PDE5 inhibitor powder formulations and methods relating thereto

Provided herein are methods for treating pulmonary hypertension. The methods include administering to a subject in need thereof an effective amount of a vasodilator, wherein the vasodilator is administered to the subject via inhalation pro re nata using a portable inhaler. In some embodiments, the vasodilator is a PDE5 inhibitor. Pharmaceutical compositions for pro re nata administration of vasodilators are also described.

Methods and compositions for treatment of pulmonary hypertension and other lung disorders

A dry powder inhaler includes a powder storage element configured to hold a powdered medicament and an inlet channel receives powdered medicament from the powder storage element that is entrained in an airflow. The inlet channel has a first diameter and defines an opening. The inhaler includes a dispersion chamber that receives the airflow and the powdered medicament from the opening. The dispersion chamber has a second diameter. The inhaler includes an actuator housed within the dispersion chamber. The actuator oscillates within the dispersion chamber when exposed to the airflow to deaggregate the powdered medicament entrained by the airflow passing through the dispersion chamber. A ratio between the first diameter and the second diameter is between about 0.40 and 0.60 such that an audible sound is produced as the actuator oscillates. The inhaler includes an outlet channel through which the airflow and powdered medicament exit the inhaler.

Powder dispersion methods and devices

Methods for treatment of pulmonary hypertension

Powder inhaler, system and methods

A dry powder inhaler may include a powder storage region, an inlet channel, a dispersion chamber, and an outlet channel. A geometry of the inhaler may be such that a flow profile is generated within the dispersion chamber that causes an actuator to oscillate, enabling the actuator when oscillating to deaggregate powdered medicament within the dispersion chamber to be aerosolized and entrained by the air and delivered to a patient through the outlet channel.

Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents

A hand-held scrubbing tool is formed with an upper dome portion and an incorporated cylindrical base portion which has a predetermined diameter and a generally circular bottom surface. The tool is favorably formed of a comfortable, flexible urethane rubber material that has a durometer value of about 30 A. Hook type material is embedded into the bottom surface of the base portion and is adapted to permit a scrub pad, sanding pad, or the like to be secured to it. The tool may have a design with protruding, tactile features that facilitate a comfortable grip on the tool.

Handheld scrubbing tool

A tissue closure device including a tissue eversion apparatus, and a first and a second, redundant closure element that are placed on the external surface of a tissue puncture wound to enhance the efficacy of closure. The first closure element and the second closure element are left resident on the external surface of or in proximity to the tissue puncture wound in order to provide redundancy of closure.

Redundant tissue closure methods and apparatuses

Sewage water with entrained solids as an effluent is fed into the trough bottom shaped process tank that is a totally enclosed tank other than for inlets and outlets therefore. The system disposes of water from sewage effluents and also residual solids thereof and is fed sewage to a controlled depth in a tank trough with high temperatures used to sterilize the effluent. A two-speed motor driven mixer driven at low speed continually mixes and blend the sewage effluent at the same time air from a blower is bubbled through the mixture. Heat is added to increase water vapor saturation capability of the air flow through the system. The air/vapor mixture flows through a recuperative heat exchanger supported within the tank above the surface of sewage effluent contained therein, absorbing heat with flow, through a catalyst bed in a chamber with circulation through the heat exchanger and on out an exhaust vent with impurities oxidized and vented with air flow. Heating elements subject to power control heat the tank and the heat exchanger.

Growing community of inventors

Santa Fe, NM, United States of America

Robert Curtis