The Brigham and Women's Hospital, Inc.

Dana-farber-cancer Institute Inc.

Northeastern University

Robert Cormack

Gerassimos M Makrigiorgos

Srinivas Sridhar

Wilfred F Ngwa

Rajiv Kumar

A method of detecting migration of tumor cells is provided by implanting in a region of tumor cells one or more implants having a matrix material of a biocompatible and biodegradable polymer, and a plurality of nanoparticles dispersed within the matrix material and functionalized to bind tumor cells. Nanoparticles bound to the tumor cells that have migrated out of the region can be detected by various imaging modalities. The implant can be in the shape of a brachytherapy spacer or radiotherapy fiducial maker or can be a coating on a brachytherapy spacer or fiducial marker. A method of treating cancer is provided by implanting one or more brachytherapy spacers or fiducial markers including the matrix material and an anti-cancer therapeutic agent dispersed within the matrix material.

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Milton, MA, United States of America

Robert Cormack