Semba Biosciences, Inc.

Tosoh Bioscience LLC

Robert Charles Mierendorf

Scott Gerald Manke

Brian A Harbrecht

Anthony Charles Grabski

Andrew Paul Wilke

Cunjiang Cheng

Anil Rajaram Oroskar

Joerg Werner Baier

James L Rane

Herbert Edmund Paaren

An illustrative valve block includes a plate, a fluid transfer block, and a diaphragm. The plate includes a channel configured to receive a first fluid and a recess connected to the channel. The fluid transfer block includes an inlet connection configured to receive a second fluid and an outlet connection. The fluid transfer block also includes a plurality of valve inlet bores connected to the inlet connection. The plurality of valve inlet bores are distributed along at least part of a first curved shape. The fluid transfer block further includes a plurality of valve outlet bores each fluidly connected to the outlet connection. The plurality of valve outlet bores are distributed along at least part of a second curved shape. The diaphragm is between the pressure plate and the fluid transfer block. The plurality of valve inlet bores and the plurality of valve outlet bores adjoin the recess.

High-flow fluid valve block

A valve block includes a fluid-transfer plate with multiple inlet bores connecting to a common inlet channel, and multiple outlet bores connecting to a common outlet channel. The inlet bores and the outlet bores are arranged in a curved shape. The valve block also includes a pressure plate and diaphragm aligned and connected to the fluid-transfer plate in a way that allows pressurized material in the pressure plate to control the state of the channels formed by the inlet and outlet bores.

An illustrative valve block includes a pressure plate, a fluid transfer block, and a diaphragm. The pressure plate includes a pressure channel configured to receive a pressurized first fluid and a recess in a surface of the pressure plate. The pressure channel and the recess are fluidly connected. The fluid transfer block includes an inlet connection configured to receive a second fluid and an outlet connection. The fluid transfer block also includes a plurality of valve inlet bores each fluidly connected to the inlet connection. The plurality of valve inlet bores are distributed along at least part of a first circular shape. The fluid transfer block further includes a plurality of valve outlet bores each fluidly connected to the outlet connection.

An improvement in a valve block for use with diaphragm-based valves is disclosed. The valve block includes a fluid-transfer plate with multiple small-diameter inlet bores connecting to a common inlet channel, and multiple small-diameter outlet bores connecting to a common outlet channel. The valve block also includes a pressure plate and diaphragm aligned and connected to the fluid-transfer plate in a way that allows pressurized material in the pressure plate to control the state of the channels formed by the inlet and outlet bores. The sizing and number of bores is optimized to accommodate high fluid flow rates, control fluid pressure, and enhance reliability.

A device to enhance sealing is provided. The device includes a body and a pressure cup. The pressure cup includes a channel, a first pressure channel, and a second pressure channel. The channel is formed in a surface of the body to surround a first portion of the surface. The channel is configured to hold an o-ring. The first pressure channel extends through the body and opens into the first portion of the surface. The second pressure channel extends through the body and opens into the channel. Pneumatic pressure within the second pressure channel is controlled to hold the o-ring in the channel when a second pressure within the first pressure channel changes.

Valve block assembly

The present invention provides devices and methods for micro-scale simulated moving bed chromatography (SMB) for continuous preparation of analytic quantities of highly pure fractions of target molecules. The present apparatus and method of the invention is adapted in a preferred embodiment to separations by affinity chromatography involving three discontinuous liquid flow loops. An alternative embodiment of affinity chromatography utilizes standard SMB operating under isocratic conditions.

Valve module and methods for simulated moving bed chromatography

A carriage holder for support of an apparatus includes identical upper and lower support plates having on their outer edge a number of indentations corresponding to the number of apparatus to be supported, said indentations providing aligned radial horizontal grasping surfaces on one side of said apparatus. The carriage holder also includes a series of vertical spring pivot pins joining said upper and lower support plates, adjacent to each said indentation, each such pin bearing a torsion spring loaded retractable clamp member to provide grasping surfaces in retracted position opposite to the grasping surfaces of said indentations. The carriage holder also includes an unobstructed aperture in each of said aligned support plates for mounting said carriage holder on a shaft. The carriage holder further includes a locking mechanism to hold said carriage in a fixed position on the shaft.

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Verona, WI, United States of America

Robert Charles Mierendorf