Tetra Discovery Partners, LLC

Other

Robert Campbell

Mark E Gurney

Timothy J Hagen

Donna Lee Romero

Joel R Walker

Lei Zhu

Xuesheng Mo

A Samuel Vellekoop

The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.

Heteroaryl inhibitors of PDE4

A thin film Brewster coupling device configured for low loss transmission of an imposed polarized parallel to plane of incidence 8.5 micron to 11.5 micron wavelength laser beam and simultaneous high reflectivity of a polarized perpendicular to plane of incidence 2 micron to 4 micron wavelength laser beam. The device comprising an optical media substrate and at least one dielectric stack optically coupled to the optical media substrate where the dielectric stack comprises a dielectric layer and an overlayer, the dielectric layer and the overlayer each comprising a thickness of nominally a quarter wavelength of the 2 micron to 4 micron wavelength laser beam, and oriented at near the Brewster Angle to the incident 8.5 micron to 11.5 micron wavelength laser beam. The substrate and dielectric mediums of necessary characteristics to result in low LIDT, high strength, chemical inertness and high thermal conductivity.

Thin film brewster coupling device

Efficient laser diode excited Thulium (Tm) doped solid state systems, directly matched to a combination band pump transition of Carbon Dioxide (CO), have matured to the point that utilization of such in combination with COadmits effectively a laser diode pumped COlaser. The laser diode excited Tm solid state pump permits Continuous Wave (CW) or pulsed energy application. Appropriate optical pumping admits catalyzer free near indefinite gas lifetime courtesy of the absence of significant discharge driven dissociation and contamination. As a direct consequence of the preceding arbitrary multi isotopologue CO, symmetric and asymmetric, gas mixes may be utilized without significant degradation or departure from initial mix specifications. This would admit, at raised pressure, a system continuously tunable from approximately 9 &#x3bc;m to approximately 11.5 &#x3bc;m, or sub picosecond amplification. This method offers advantages in regards scalability, pulse energy and power, over alternative non linear conversion techniques in access to this spectral region.

CO2 laser

The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of disease.

A practical, limited pulse train EMP source, with unitary or phased up capability, reliant on electrical pulse power systems integrated with low timing jitter switching, transformation lines and impedance matched antenna to generate an intense electromagnetic pulse train.

Scalable, modular, EMP source

The closed cycle solid state optically pumped gas hybrid (chemical recovery) system utilizes a laser diode excited solid state, fiber or bulk, laser as a pump for a molecular gas, or gas mix, medium. The existence of efficient high power laser diode excited solid state fiber or bulk lasers, output spectrally matched to suitable principle and excited level 1and 2overtones of relevant gases, is the enabling system technology. The utilization of such in combination with suitable gases introduces a range of viable, in principle sourcing on laser diodes and thus effectively laser diode pumped, gas laser systems with access to the approximately 4.5 &#x3bc;m to approximately 5.4 &#x3bc;m spectral region. Continuous wave or pulsed operation, with significant energy capability courtesy of solid state storage, is admitted.

Molecular gas laser

Efficient laser diode excited Thulium (Tm) doped solid state systems, directly matched to a combination band pump transition of Carbon Dioxide (CO), have matured to the point that utilization of such in combination with COadmits effectively a laser diode pumped COlaser. The laser diode excited Tm solid state pump permits Continuous Wave (CW) or pulsed energy application. Appropriate optical pumping admits catalyzer free near indefinite gas lifetime courtesy of the absence of significant discharge driven dissociation and contamination. As a direct consequence of the preceding arbitrary multi isotopologue CO, symmetric and asymmetric, gas mixes may be utilized without significant degradation or departure from initial mix specifications. This would admit, at raised pressure, a system continuously tunable from approximately 9 &#x3bc;m to approximately 11.5 &#x3bc;m, or sub picosecond amplification. This methodology offers advantages in regards scalability, pulse energy and power over alternative non linear conversion techniques in access to this spectral region.

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A railgun launcher with principle rail energization and fielding derived from a co-traveling energy pulse associated with a close-coupled parallel transmission line structure. Enhanced system efficiency, plus amelioration of simple railgun negative features, is enabled via the induction hybrid railgun methodology proposed.

Traveling wave augmented railgun

The closed cycle solid state optically pumped gas hybrid (chemical recovery) system utilizes a laser diode excited solid state, fiber or bulk, laser as a pump for a molecular gas, or gas mix, medium. The existence of efficient high power laser diode excited solid state fiber or bulk lasers, output spectrally matched to suitable principle and excited level 1st and 2nd overtones of relevant gases, is the enabling system technology. The utilization of such in combination with suitable gases introduces a range of viable, in principle sourcing on laser diodes and thus effectively laser diode pumped, gas laser systems with access to the approximately 3.5 &#x3bc;m to approximately 5.2 &#x3bc;m and approximately 9 &#x3bc;m to approximately 11 &#x3bc;m spectral regions. Continuous wave or pulsed operation, with significant energy capability courtesy of solid state storage, is admitted.

Growing community of inventors

Niskayuna, NY, United States of America

Robert Campbell