Zimmer Gmbh

Depuy Acromed, Inc.

Orquest, Inc.

Depuy Spine, Inc.

Isto Technologies, Inc.

Carbylan Therapeutics, Inc.

Robert C Spiro

Cheryl Renee Blanchard

Neil Kizer

LinShu Liu

Jian Yao

Lin Shu Liu

Andrea Y Thompson

Mohammad A Heidaran

Robin Daverman

David M Gravett

George Y Daniloff

Mitchell S Seyedin

Pingren He

H Davis Adkisson, Iv

Mohammad Heidaran

Patrick J Hillas

Iv H Davis Adkisson

The present application provides sterile hyaluronic polymer compositions than are useful, e.g., as medical devices, biomedical adhesives, and sealants. Generally, provided are sterile dry compositions comprising a thiol-derivatized hyaluronic acid and one or more stabilizing excipients. Also provided are related kits and methods. The compositions described herein are particularly robust to sterilizing irradiation, and substantially maintain both their molecular weight and gelation parameters such as gelation time after sterilization, such that such sterile compositions are capable of hydrogel formation.

Sterile hyaluronic acid polymer compositions and related methods

The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.

Treatment methods using a particulate cadaveric allogenic juvenile cartilage particles

Particulate cadaveric allogenic cartilage system

Disclosed in the present application are compositions comprising a bioresorbable polymer matrix and a bio active agent, wherein the bioactive agent is dispersed within polymer matrix as a solid. Also provided herein are methods for preparing a bioactive agent formulation, wherein the agent is present in a solid form and, wherein the agent is occluded into a polymeric matrix by polymerization of polymer matrix precursors or by self assembly of the polymer.

Polymer formulations for delivery of bioactive agents

Particulate cartilage system

Juvenile cartilage composition

Cadaveric allogenic human juvenile cartilage implant

Method of treating an osteochondral defect

The present application discloses matrix compositions to support the repair of tissue defects such as an osteochondral injury. A matrix described herein comprises a polyester polymer entangled with a polysaccharide polymer. Also disclosed are methods of preparing a matrix, and methods of using a matrix in the repair of tissue. In certain configurations, a matrix can comprise a polyester cross-linked with a polysaccharide, which can be an oxidized polysaccharide. In some configurations, a matrix can further comprise one or more additional components, such as a growth factor.

Matrix made of polyester polymers entangled with hyaluronic polymers useful for supporting tissue repair

The present application discloses compositions, methods and devices for treatment of a degenerative intervertebral disc. A composition can comprise chondrocytes expressing type II collagen. These chondrocytes can be obtained from human cadavers up to about two weeks following death, and can be grown in vitro. The compositions can further comprise one or more biocompatible molecules. Treatment of a degenerative disc can comprise injecting or implanting a composition comprising the chondrocytes into a degenerative disc.

Intervertebral disk repair, methods and devices therefor

A method and composition are provided for inducing or enhancing chondrogenesis in vivo or in vitro. The method is performed by exposing the cells in vitro or in vivo to an extracellular matrix comprising of type I collagen, type II collagen or a mixture of type I collagen or type II collagen and hyaluronate and further containing GDF-5.

Method of inducing or enhancing chondrogenesis with extracellular matrix containing GDF-5

A carrier and a method for preparing it are provided for use in the delivery of therapeutic agents. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to form aldehyde groups. The aldehyde groups are reacted to form covalent oxime linkages with a second polysaccharide and each of the first and second polysaccharide is selected from the group consisting of hyaluronic acid, dextran, dextran sulfate, chondroitin sulfate, dermatan sulfate, keratan sulfate, heparan, heparan sulfate and alginate.

Cross-linked polysaccharide drug carrier

Disclosed are bilayer matrices of a polysaccharide such as collagen (COL) and another polysaccharide such as hyaluronic acid (HA) with various COL/HA ratios. Each layer has a porous structure. These materials are useful for tissue regeneration, particularly when used with orthopedic implants and drug delivery.

Collagen/polysaccharide bilayer matrix

Growing community of inventors

Half Moon Bay, CA, United States of America

Robert C Spiro