Baxter International Inc.

Other

Edwards Lifesciences Corporation

Robert C Peterson

Donald T Shannon

Chris Kuo

Chris McCollam

John James McIntyre

Can B Hu

Keith E Myers

James C Hobson

Mikhail V Novikov

A tape-reinforced tubular vascular graft formed of sintered fluoropolymer(s), such as expanded, sintered PTFE. The graft includes a base graft and a reinforcing tape applied thereto. The tape may be spirally wrapped about the graft or spirally wrapped into a tube about a cylindrical mandrel and then applied to the exterior of the graft. Radial shrinkage of the combined base graft and tape, or of the reinforcing tape tube, renders the vascular graft subsequently radially enlargeable by more than 5%, without tearing or breaking of the reinforcement tape layer of the graft. Radially enlargeable grafts of the present invention may be combined with various types of stents or anchoring systems, to form endovascular graft devices which are transluminally insertable and implantable within the lumen of a host blood vessel. Alternatively, radially enlargeable grafts of the present invention may be implanted by way of traditional surgical graft implantation techniques, without any radial enlargement of the graft at the time of implantation, so as to take advantage of the improved strength properties and suture-holding properties of the radially-shrunken tape-reinforced grafts of the present invention.

Radially-expandable PTFE tape-reinforced vascular grafts

An automated water discharging system for prohibiting buoyant debris from reaching and engaging an existing support structure that is partially submerged in an existing body of water may include a mechanism for extracting and channeling water from beneath a water line to above a water line of the existing body of water. Additionally, a mechanism for distributing water from above the water line to a plurality of third locations may be included by creating an artificial current flowing away from the existing support structure. A plurality of conduits and a power-actuated pump may direct the water and debris from one location to the next. Discharge nozzles may discharge the water at an angle defined downwardly towards the water line to thereby create the artificial current leading away from the existing support structure. A controller may be included to adjust the flow rate of the nozzles and the corresponding artificial current.

Floating weed and debris removal system and associated method

A tape-reinforced tubular vascular graft formed of sintered fluoropolymer(s), such as expanded, sintered PTFE. The graft includes a base graft and a reinforcing tape applied thereto. The tape may be spirally wrapped about the graft or spirally wrapped into a tube about a cylindrical mandrel and then applied to the exterior of The graft. Radial shrinkage of the combined base graft and tape, or of the reinforcing tape tube, renders the vascular graft subsequently radially enlargeable by more than 5%, without tearing or breaking of the reinforcement tape layer of the graft. Radially enlargeable grafts of the present invention may be combined with various types of stents or anchoring systems, to form endovascular graft devices which are transluminally insertable and implantable within the lumen of a host blood vessel. Alternatively, radially enlargeable grafts of the present invention may be implanted by way of traditional surgical graft implantation techniques, without any radial enlargement of the graft at the time of implantation, so as to take advantage of the improved strength properties and suture-holding properties of the radially-shrunken tape-reinforced grafts of the present invention.

Radially expandable tape-reinforced vascular grafts

An apparatusfor producing one or more characterizing measurements of a surfacein relation to a repeatedly reproducible datum axis A-A, the apparatuscomprising a probea first porous surfacelocated on the probethe first porous surfacebeing in communication with a first source of fluid pressurethe first porous surfacebeing located proximate to opposing wallsthat defines a volumeso that a non-contacting fluid pressure gapis formed between the first porous surfaceand the wallsthe first porous surfacedefining the datum axis A-A; at least one second porous surfacelocated on the probethe at least one second porous surfacebeing in communication with a second source of fluid pressurethe at least one second porous surfacebeing located in a cooperative relationship with the surfaceto be measured, so that a non-contacting fluid pressure gapis fanned between the at least one second porous surfaceand the surface to be measured; and means for generating one or more characterizing measurements of the surface to be measured in relation to the datum axis.

Fluid-aligned measurement apparatus and method

A method for improving the radial enlargeability and other properties of tape-reinforced tubular vascular graft formed of sintered fluoropolymer(s), such as expanded, sintered PTFE. Broadly, the method comprises the step of radially shrinking the reinforcement tape layer of the graft, or the entire tape-reinforced graft, after sintering thereof. Such radial shrinkage of the reinforcement tape layer, or of the entire graft, renders the graft subsequently radially enlargeable by more than 5%, without tearing or breaking of the reinforcement tape layer of the graft. Radially enlargeable grafts of the present invention may be combined with various types of stents or anchoring systems, to form endovascular graft devices which are transluminally insertable and implantable within the lumen of a host blood vessel. Alternatively, radially enlargeable grafts of the present invention may be implanted by way of traditional surgical graft implantation techniques, without any radial enlargement of the graft at the time of implantation, so as to take advantage of the improved strength properties and suture-holding properties of the radially-shrunken tape-reinforced grafts of the present invention.

Process of manufacturing a radially expandable PTFE tape-reinforced vascular graft

Porous fluoropolymer films, such as PTFE films, formed by a method including the steps of (a) forming a fluoropolymer (e.g., PTFE) paste, (b) extruding, calendaring, or otherwise processing the paste to form a film extrudate, (c) causing the film extrudate to be calendared in a first directional axis, (d) subsequently calendaring the film extrudate in a second directional axis which is different from the first directional axis, (e) subsequently calendaring the film extrudate in at least one additional directional axis which is different from said first and second directional axes, thereby forming a multiaxially calendared film extrudate, (f) drying the multiaxially calendared film extrudate, and (g) radially expanding the multiaxially calendared film extrudate to form a radially oriented fluoropolymer (e.g., PTFE) film. The porous fluoropolymer films formed by this method are multiaxially oriented and exhibit isotropic strength properties.

Methods of manufacture of multiaxially oriented fluoropolymer films

Disclosed herein are methods for harvesting adipose tissue so as to preserve an increased population of viable microvascular endothelial cells. Adipose tissue containing microvascular endothelial cells is harvested using a collection apparatus incorporating an elongate cannula having apertures with tissue cutting edges. A sub-ambient pressure is applied to a lumen in the cannula to draw the adipose tissue through the aperture where it is then severed using the cutting edge to disrupt the connective adipose matrix. This harvesting provides a cleaner, more homogeneous sample of adipose tissue, thereby increasing the population of viable microvascular endothelial cells obtained through further processing. Rapid and easy methods for the further homogenization of the harvested adipose tissue are also disclosed.

Devices for harvesting and homogenizing adipose tissue containing

An externally supported, tape-reinforced tubular prosthetic graft and method of manufacturing therefore. The graft comprises a tubular base graft formed of expanded, sintered fluoropolymer material, a strip of reinforcement tape helically wrapped about the outer surface of the tubular base graft and attached thereto, and, an external support member helically wrapped around the outer surface of the reinforcement tape and attached thereto. The helical pitch of the reinforcement tape is different from the helical pitch of the external support member. Preferably, the helical pitch of the reinforcement tape is in a direction which is opposite the direction of the external support member.

Method of forming an externally supported tape reinforced vascular graft

Radially-enlargeable PTFE tape-reinforced vascular grafts and their

Methods for harvesting adipose tissue containing autologous

Method of manufacturing a radially-enlargeable PTFE tape-reinforced

A method for preparing thin fluoropolymer (PTFE) films, said method generally having the steps of: a) providing an unsintered fluoropolymer film; b) pre-sintering expansion of the film; c) sintering the expanded film with dimensional restraint to prevent shrinkage; and d) post-sintering stretching of the film to a final thickness preferably less than 0.002 inches. The post-sintering stretching of the film in step d may be accomplished in a single step, or may include a series of post-sintering stretching steps. Steps b and c of the method may be carried out bypassing the calendared film through a machine direction orienter device and, thereafter, step d of the method may be accomplished by subsequently repassing the sintered film through the machine direction orienter device, one or more additional times.

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Dove Canyon, CA, United States of America

Robert C Peterson