Dana-Farber-Cancer Institute Inc.

Burnham Institute for Medical Research

Robert C Liddington

Wayne A Marasco

Jianhua Sui

George Rainer Siber

Adolf Hoess

Disclosed are antibodies that bind to the stem region of influenza hemagglutinin in the neutral pH conformation, hemagglutinin epitopes to the stem region, and methods of making and using both.

Conserved hemagglutinin epitope, antibodies to the epitope, and methods of use

The invention provides human scFv antibodies and monoclonal antibodies that neutralize influenza virus. Also provided are methods of treating and/or preventing a influenza related disease or disorder such bird flu The invention also provides methods of vaccinating a patient against influenza. Also provided are methods of diagnosing influenza-related diseases or disorders and methods of detecting the presence of a influenza in a sample.

Antibodies against influenza virus and methods of use thereof

Substance which bind with high affinity to endotoxin (lipopolysaccharide &lsqb;LPS&rsqb;), and which are useful for the prevention or treatment of, for example, Gram-negative and Gram-positive bacterial sepsis, and for the treatment of bacterial and fungal infections as well as for neutralizing effects associated with heparin. The substances are LPS-binding peptides comprising an LPS-binding domain. DNA sequences encoding peptides, recombinant microorganisms containing the DNA, pharmaceutical compositions containing the peptides of the invention, and diagnostic kits. Methods for the detection and removal of bacterial LPS from solutions.

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La Jolla, CA, United States of America

Robert C Liddington