Parallel Synthesis Technologies

Symyx Technologies, Inc.

Emerald Biosystems, Inc.

Robert C Haushalter

Leonid Matsiev

Lynn Van Erden

Shenheng Guan

Ravi Srinivasan

Xiao Ping Zhou

Christopher J Warren

Xuejun Jason Wang

Robert W Haushalter

Eric W McFarland

Martin Devenney

Xiao-Dong Sun

Earl Danielson

Dean Allyn Hopkins, Jr

Alexandrina Muntianu

Peter Nollert

The invention relates to a composition, method and apparatus for determining the sequence of a nucleic acid strand utilizing a pH-sensing agent.

Nucleic acid sequencing technique using a pH-sensing agent

A rare earth (RE) downconverting phosphor composition may contain two or more lanthanide materials each having a host and at least one downconverting emitter. Each lanthanide material emits a detectable electromagnetic radiation emission peak at an intensity, which is proportional to the amount of emitter present, upon excitation with an absorbable electromagnetic radiation, the emitted radiation having a lower energy, i.e., a longer wavelength than the absorbable radiation. One or more ratios of the intensities of the emitted detectable electromagnetic radiation may be used to uniquely identify the composition. Alternatively, the RE downconverting phosphor composition may contain a lanthanide material having a host and at least two emitters. The lanthanide material emits at least two different detectable electromagnetic radiation emission peaks each at an intensity upon excitation with an absorbable electromagnetic radiation, the emitted radiation having a lower energy, i.e., a longer wavelength than the absorbable radiation.

Rare earth downconverting phosphor compositions for optically encoding objects and methods and apparatus relating to same

The present invention relates generally to encoding samples. More specifically, it relates to barcodes and compositions involving upconverters and methods including them. In a composition aspect of the invention, a composition comprising two or more lanthanide materials is provided. Each lanthanide material comprises a host, an absorber, and an emitter, and the materials emit detectable electromagnetic radiation upon excitation with absorbable electromagnetic energy. One or more relative ratios of emission intensities uniquely identify the composition.

Methods for optically encoding an object with upconverting materials and compositions used therein

Rare Earth downconverting compositions for optical encoding objects and related methods and apparatuses. The rare earth (RE) downconverting phosphor compositions are capable of generating a unique optical spectrum or unique optical signature from which an optical code or barcode can be derived. In one exemplary embodiment, the RE downconverting phosphor composition may contain two or more lanthanide materials each having a host and at least one downconverting emitter. Each lanthanide material emits a detectable electromagnetic radiation emission peak at an intensity, which is proportional to the amount of emitter present, upon excitation with an absorbable electromagnetic radiation, the emitted radiation comprising a lower energy, i.e., a longer wavelength than the absorbable radiation. One or more ratios of the intensities of the emitted detectable electromagnetic radiation may be used to uniquely identify the composition. In another exemplary embodiment, the RE downconverting phosphor composition may contain a lanthanide material having a host and at least two emitters. The lanthanide material emits at least two different detectable electromagnetic radiation emission peaks each at intensity upon excitation with an absorbable electromagnetic radiation, the emitted radiation comprising a lower energy, i.e., a longer wavelength than the absorbable radiation.

A method for labeling an object such as a biological sample, including printing at least two different light-emitting species onto a substrate which are capable of displaying a unique optical signature when excited; and externally attaching the object to the printed at least two different light-emitting species. Also, a method for conducting a large scale test, including printing a first label onto a first substrate, the first label comprising at least two different light-emitting species capable of displaying a first unique optical signature when excited; printing a second label onto the first substrate or a second substrate, the second label comprising at least two different light-emitting species capable of displaying a second unique optical signature when excited; externally attaching a first object, such as a first biological sample to the first label; externally attaching a second object, such as a second biological sample to the second label; processing the first and second objects in a combined manner; analyzing the processed first and second objects; and identifying the analyzed first and second objects using their respective first and second labels.

Methods for fabricating optically encoded particles and methods for optically encoding objects with such particles

Systems and methods are provided for dispensing portions of viscous material, such as the viscous materials used to form crystals of membrane proteins or soluble proteins. A liquid under pressure is used to divide the viscous materials into portions. The divided viscous material portions can optionally be deposited into are receptacle.

Systems and methods for dispensing portions of viscous material

The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of vessels for containing individual library members and a fluid handling system that apportions a test fluid about equally between each of the vessels. This allows for simultaneous screening of library members by detecting changes in test fluid following contact with individual library members. Fluid flow through each of the vessels is controlled using passive flow restrictors or active flow controllers to ensure that each library member contacts approximately the same amount of test fluid per unit time. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.

Apparatus for screening catalysts in a parallel fixed-bed reactor

Crystallization Photoresist (PR) apparatus and methods which allow for fast screening and determination of protein crystallization conditions with small protein quantities and rapid crystallization. The apparatus comprise a first region comprising a first nucleation catalyst material and a second region comprising a second nucleation catalyst material, with the first and second regions positioned adjacent to each other and configured to support at least one crystal, and with the first region having a variation in a nucleation property of the first nucleation catalyst material in the first region. The crystal may be supported at an interface of the adjacent regions. The methods comprise providing a first region of a first nucleation catalyst material and a second region of a second nucleation catalyst material adjacent said first region, with the first region having a variation in a nucleation property of the first nucleation catalyst material, exposing the first and second regions to a solution of a selected molecule, and growing at least one crystal of the molecule in association with the first and second regions.

Methods and devices for high throughput crystallization

Methods for screening catalysts in a parallel fixed-bed reactor

An electrochemical deposition and testing system consisting of individually addressable electrode arrays, a fully automated deposition head, and a parallel screening apparatus is described. The system is capable of synthesizing and screening millions of new compositions at an unprecedented rate.

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Los Gatos, CA, United States of America

Robert C Haushalter