Advanced Cardiovascular Systems, Inc.

Robert C Esselstein

Wayne E Cornish

David H Burkett

Douglas H Gesswein

Mark Richardson

Daryush Mirzaee

David K Wrolstad

David M Anderson

Marc Mehrzad Jalisi

Olin J Palmer

James M Jacobs

Emmanuel C Biagtan

Kent C Stalker

John Schreiner

Lawrence E Brennan

Philip S Yip

Ryan Grandfield

Aaron Baldwin

Pablito Buan

Kathern J Lind

Robert C Hazelden

Thomas Tokarchik, Iii

William Earl Webler, Jr

W Stan Wilson

Mina W Chow

Srinivasan Sridharan

Jessica G Chiu

Nianjiong Joan Bei

Gregory Waimong Chan

Stephen G Schaible

Hongzhi Bai

Gabriel Asongwe

Thomas Ray Hatten

Yan Shen

Mark J Bly

Henry Nita

Sepehr Fariabi

Leonard Darius Barbod

Brandon Gosiengfiao

Embodiments include an infusion-occlusion system having a delivery catheter, a guide catheter adapted to receive the delivery catheter, and a guidewire with an occlusion device adapted to be received within the guide catheter. The guide catheter of the catheter kit may be provided with an occlusion device at the distal end of the guide catheter. The delivery catheter may have an accessory lumen, coaxial or co-linear lumen, a supporting mandrel, or an occlusion device at its distal end. Moreover, according to some embodiments, occlusion devices may be a single material or a composite balloon having an inner liner and an outer layer of different materials, a high compliance low pressure balloon, or a filter device that restricts particles from passing through but does not restrict fluid, such as blood. An inflation device with a large volume and low volume syringe can be used to inflate the balloon.

Infusion treatment agents, catheters, filter devices, and occlusion devices, and use thereof

A locking component for locking a medical device onto a guide wire. Such medical devices include, for example, an embolic filter assembly used to capture embolic material that may be created and released into a patient's vasculature during a stenting or angioplasty procedure. The embolic filter assembly tracks along the guide wire, and is delivered to a treatment site where it is locked in place and deployed. The locking component enables the filter assembly to lock onto any standard guide wire, and does not require a modified guide wire that has a specially-designed fitting or stop to accomplish the locking function.

Locking component for an embolic filter assembly

A guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal portion of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that is configured to produce a linear change in stiffness of the core over a longitudinal portion of the device. An embodiment has a plurality of radiopaque elements that may be intermittent, continuous or in the form of a helical ribbon for scaled measurement of intracorporeal structure under fluoroscopic imaging. Another embodiment has at least one layer of polymer over the distal end of the device.

Polymer coated guidewire

A guidewire or section thereof, that has a core member or the like with a plurality of contiguous tapered segments having taper angles that are configured to produce a linear change in stiffness over a longitudinal portion of the device. The device may also have a core section with a continuously changing taper angle to produce a curvilinear profile that is configured to produce a linear change in stiffness of the core over a longitudinal portion of the device. An embodiment has a plurality of radiopaque elements that may be intermittent, continuous or in the form of a helical ribbon for scaled measurement of intracorporeal structure under flouroscopic imaging. Another embodiment has at least one layer of polymer over the distal end of the device.

Polymer coated guide wire

The invention is directed to an guide wire for intraluminal deployment of a medical device within a patient, the guide wire having an elongate core member with an intermediate core section comprising a plurality of contiguous segments in alignment with the longitudinal axis of the core member with alternating flexible and rigid core segments, so that the articulated section bends in a discontinuous, discrete manner when advanced through a curved blood vessel or other body lumen within the patient. When an obstruction on a vessel wall causes the catheter or other coaxial device to be impeded, the guide wire and intermediate core section may alternately be advanced and retracted a short distance through the catheter distal tip causing a &ldquo;nodding&rdquo; motion of the catheter tip while the catheter is pushed through the vessel, so as to avoid and bypass the vessel obstruction.

Guidewire with an intermediate variable stiffness section

A guidewire having a proximal hypotube portion with an insert to increase pushability and torqueability. The insert may comprise metals such as stainless steel, shape memory/super elastic materials such as nickel titanium alloys, composite materials or polymeric materials. The proximal end of the insert may be configured to dock with an extension guidewire. Preferably, the proximal end of the solid core distal portion of the guidewire is configured to fit within the hypotube and the two are secured by adhesive, solder or the like.

Guidewire with hypotube and internal insert

The ultrasonic angioplasty transmission wire has regions of reduced cross-sectional diameter to improve flexibility of the ultrasonic angioplasty transmission wire and to compensate for degradation of longitudinal displacement due to acoustic losses along the length of the ultrasonic angioplasty transmission wire. One or more constraining members are disposed on the ultrasonic angioplasty transmission wire at one or more of the regions of reduced cross-sectional diameter where transverse vibration of ultrasonic energy transmitted by the ultrasound transmission wire is amplified, to constrain transverse vibration at these areas to reduce stress and reduce fracturing, while allowing longitudinal movement. The transmission wire has an elongated shaft including, in atomic percent, from about 28 to about 52 percent nickel, from about 48 to about 52 percent titanium, and up to about 20 percent of at least one alloying element selected from the group consisting of palladium, chromium, and hafnium.

Ultrasonic angioplasty transmission member

The invention is directed to a catheter system having an ultrasonic delivery device, a dilatation balloon, and a stent. The ultrasonic distal head is used to ablate a lesion permitting the dilation balloon to cross the lesion for dilatation and for delivering the stent to the lesion. A catheter body includes a first lumen for dilatation balloon expansion control fluid, and a second lumen for the guide wire. The ultrasonic distal head includes a guide wire aperture large enough to permit complete retraction of the guide wire so that the guide wire may be replaced with another while the catheter remains in place within the vasculature of the patient.

Ultrasonic catheter vascular stent system and method

Growing community of inventors

Fallbrook, CA, United States of America

Robert C Esselstein