K.v. Pharmaceutical Company

Drugtech Corporation

Norcliff Thayer Inc.

Kv Pharmaceuticals Company

Perrigo Pharma International Designated Activity Company

Kv Pharmaceutical Corporation

Robert C Cuca

R Saul Levinson

Mitchell I Kirschner

Keith S Lienhop

George N Paradissis

Thomas C Riley

Thomas Charles Riley, Jr

Gary Heeter

Patrick Paul Vanek

Yury Lagoviyer

Ronald S Harland

Elio Mariani

Hans C Beinke

A pharmaceutical formulation to treat vaginal conditions in a human patient comprises:

Pharmaceutical delivery system

A pharmaceutical delivery system that releases an active agent in a controlled manner for an extended period in the vaginal cavity to treat or cure ailments associated with the vaginal cavity or proximal areas. The delivery system includes an applicator which is composed of a high internal phase emulsion, allowing the delivery system to adhere to the mueosal surfaces of the body, primarily the lining of vaginal cavity. The delivery system can maintain the high internal phase emulsion at a temperature of 86&#xb0; F. for at least one month, without decomposition or instability of the emulsion.

Delivery system

Multi-vitamin and mineral supplements for administration to non-lactating women, which comprise specific regimens of vitamins and minerals tailored to meet the physiological needs of said women. Methods for optimizing the health of women by providing multi-vitamin and mineral supplements which are specifically tailored to achieve optimal regulation of growth, maintenance and repair of body tissue during specific stages of life with minimal side effects. Methods for formulating a multi-vitamin and mineral supplement that optimize the health of a woman and which comprise identifying life stages which correlate to specific nutritional requirements as a result of varying physiological conditions during a lifetime and selecting specific types and optimal amounts of vitamins and minerals for said life stages.

Multi-vitamin and mineral supplements for women

Multi-vitamin and mineral supplements for administration to a pregnant woman during her first, second, and third trimesters of pregnancy comprising specific regimens of a pharmaceutically acceptable calcium compound, vitamin D, folic acid, vitamin B,, vitamin B,, and vitamin B,. The prenatal supplements are specifically tailored to maximize fetal development and maternal health during each trimester of pregnancy.

Multi-vitamin and mineral supplement for pregnant women

Multi-vitamin and mineral supplements for administration to lactating, non-lactating, and menopausal women, which comprise specific regimens of critical nutritional agents. The supplements are specifically tailored to meet nutritional requirements and maintain a woman's health during each stage of life.

A bioadherent, orally ingestible system, which comprises: a water-in-oil emulsion system having at least two phases, one phase comprises from about 75% to about 99% by volume of an internal hydrophylic phase and the other phase comprises from about 25% to about 1% by volume of an external hydrophobic phase, wherein the external hydrophobic phase comprises two components, one component being about 3% to about 97% by volume of the hydrophobic phase of a hydrophobic oil and the other being about 97% to about 3% of an emulsifier having a HLB value less than about 10.

Long acting GI and esophageal protectant

A substantially tasteless liquid phramaceutical delivery system containing an active material and a high osmolarity aqueous system comprising (i) water; (ii) about 20% to about 45% by weight sugar derivative; (iii) about 10% to about 15% by weight hydrogenated maltose syrup; and (iv) about 0% to about 35% by weight polyhydroxy alcohol.

Tastemasked liquid pharmaceutical delivery system

A solid or semi-solid bioadherent, orally ingestible drug delivery system containing a water-in-oil system having at least two phases, one phase comprises from about 25% to about 75% by volume of an internal hydrophilic phase and the other phase comprises from about 25% to about 75% by volume of an external hydrophobic phase and wherein the external hydrophobic phase is comprised of three components, a) an emulsifier, b) a glyceride ester and c) a wax material.

Bioadhesive pharmaceutical delivery system

A bioadherent, orally ingestible system, which comprises: a water-in-oil system having at least two phases, one phase comprises from about 75% to about 99% by volume of an internal hydrophylic phase and the other phase comprises from about 25% to about l% by volume of an external hydrophobic phase, wherein the external hydrophobic phase comprises two components, one component being about 3% to about 97% by volume of the hydrophobic phase of a hydrophobic oil and the other being about 97% to about 3% of an emulsifier having a HLB value less than about 10.

Multi-vitamin and mineral supplements for administration to a pregnant woman during her first, second, and third trimesters of pregnancy comprising specific regimens of a pharmaceutically acceptable calcium compound, vitamin D, folic acid, vitamin B.sub.12, vitamin B.sub.6, and vitamin B.sub.1. The prenatal supplements are specifically tailored to maximize fetal development and maternal health during each trimester of pregnancy.

A substantially tasteless pharmaceutical delivery system, which comprises a) an active material; and b) a spatially oriented matrix comprising (i) a wax core material having a melting point within the range of about 50.degree. C. and about 200.degree. C.; and (ii) a regional hydrophobic polymer material and method for making the same.

Tastemasked pharmaceutical materials

A concentrated suspension of calcium carbonate particles in a liquid carrier that is compatible with a capsule shell material. The suspension is pourable and pumpable and may be used to provide antacid capsules.

Encapsulated antacid

Delivery systems for topical preparations which are commercially stable. The emulsions are water-in-oil in which the water phase comprises at least 75% of the emulsion by volume. The emulsifier is a nonionic oil soluble straight or branched chain ester or combination thereof composition having at least two hydrogen bonding sites per molecule.

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Edwardsville, IL, United States of America

Robert C Cuca