United States of America As Represented by the Administrator of Nasa

Robert C Chang

Wei Sun

Steve R Gonda

Christopher Culbertson

Heidi L Holtorf

Julia Leslie

Binil Starly

Iris Von Gustedt-Gonda, Legal Representative

A method for fabricating a micro-organ device comprises providing a microscale support having one or more microfluidic channels and one or more micro-chambers for housing a micro-organ and printing a micro-organ on the microscale support using a cell suspension in a syringe controlled by a computer-aided tissue engineering system, wherein the cell suspension comprises cells suspended in a solution containing a material that functions as a three-dimensional scaffold. The printing is performed with the computer-aided tissue engineering system according to a particular pattern. The micro-organ device comprises at least one micro-chamber each housing a micro-organ; and at least one microfluidic channel connected to the micro-chamber, wherein the micro-organ comprises cells arranged in a configuration that includes microscale spacing between portions of the cells to facilitate diffusion exchange between the cells and a medium supplied from the at least one microfluidic channel.

Micro-organ device

Growing community of inventors

Philadelphia, PA, United States of America

Robert C Chang