Orasure Technologies, Inc.

Other

Medtox

Medtox Scientific, Inc.

Robert C Bohannon

Andrew S Goldstein

Ronald William Mink

Glen Chapman

Alan Morris

Phillip Hartzog

Oluyomi Adeneye

Maria Scholz-Steele

Martin Green

Bud M Owens

Andrew Sherman Goldstein

A method for rapid collection and assay of oral fluids is disclosed. The method comprising the steps of: (a) placing an assay device into an oral cavity, (b) removing said assay device from said oral cavity; and (c) determining the presence or absence of at least one analyte. The assay device used in the method comprises: (i) an assay portion housing an immunochrornatographic lateral flow assay strip, the lateral flow assay strip containing at least one reagent selected from an antigen and an antibody that is used to detect one of the presence or absence of at least one analyte in a fluid; (ii) a neck portion extending from the assay portion, the neck portion forming a channel for delivery of fluid to said assay strip and the channel being defined by a first, narrow part proximal to the assay portion and a second part including an opening for receiving the oral fluid, wherein the second part includes a channel width that is substantially wider than the channel width at the narrow end; (iii) a collection strip in fluid communication with the lateral flow assay strip, the collection strip having a first portion disposed within the channel and a second portion protruding outwardly from the neck portion opening; and (iv) a blocking strip coupled between and in flow communication with the lateral flow assay strip and the collection strip.

Device for collection and assay of oral fluids

A device for collecting and transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. The lateral chromatographic strip is placed within and extend along a cavity defined in a housing. At least one inspection site to the lateral chromatographic strip is provided to enable inspection of selected sites on the lateral chromatographic strip for test results. A porous wick material protrudes from the housing to a collection site exterior of the housing at one end and communicates to the lateral chromatographic strip at the other end. The porous wick material has particulate construction, the particles adsorbing aqueous oral fluid to transport the fluid from the mouth to the lateral chromatographic strip without substantial absorption. The particles of the porous wick material are bound together to define a continuous interstitial volume for the flow of oral fluid to be transported and are treated to be hydrophilic to the adsorbed oral fluids. The porous wick material readily releases oral fluid to the lateral chromatographic strip. Prevention of reverse flow to the oral cavity from the lateral chromatographic strip naturally occurs due to the circuitous flow path of the porous wick material. A bite plate is coupled to the housing and insertable between the teeth of the patient to position the porous wick in the oral cavity for collecting the oral fluid. The bite plate is typically held in place by the occlusal force of the teeth, preferably the molars and/or the bicuspids, to position the porous wick in the buccal space. By observing the lateral chromatographic strip while the test device is in the mouth immediate test results are obtained.

A collection system for collecting, testing and transporting liquid biological specimens that limits exposure of a tester to the liquid sample and keeps the collected samples pristine even after exposing some of the sample to test strips. The system includes a collection body for receiving and holding a liquid sample, a lid that is coupled to the body, and a test strip housing. The lid includes a transfer conduit while the test strip housing includes an opening defined within the test strip housing. The transfer conduit and the opening are aligned when the test strip housing is coupled to the lid. When the system is moved or tilted, some of the liquid sample moves through the transfer conduit and the opening into the test strip housing.

Systems and methods for collecting, testing and transporting liquid biological specimens

The present invention provides methods, compositions, and kits for rapid detection of analytes in a sample. Surprisingly, it has been found that bulking materials having non-sugar sweeteners effectively enhance chromatographic detection methods by providing component stability and controlled release. Thus, the novel components and methods disclosed herein provide a completely new modality of chromatographic analyte detection.

Non-sugar sweeteners for use in test devices

The present invention provides methods, compositions, and kits for rapid detection of analytes in a sample. Surprisingly, it has been found that bulking materials having starch reagents effectively enhance chromatographic detection methods by providing component stability and controlled release. Thus, the novel components and methods disclosed herein provide a completely new modality of chromatographic analyte detection.

Bulking materials containing starch reagent for use in test devices

A method to reduce the physiologic effects of drugs in vivo by inducing specific anti-drug antibodies using drugs conjugated to carrier molecules so as to reduce a drug's toxicity and its physiologic effects upon the recipient. This method includes the treatment and prophylactic prevention of drug abuse, specifically for cocaine and nicotine, and to help reduce the toxic effects of drugs, such as anti-neoplastics.

Method to reduce the physiologic effects of drugs on mammals

A powerful hydrogen azide-oxygen fuel cell can be obtained by passing an aqueous solution of Hydrogen Azide (not to exceed 30% by weight) and Sodium Sulphate over a platinized electrode which forms the anode (-) of the fuel cell. Oxidation takes place at the cathode (+) by the introduction of Oxygen over a platinized electrode. The azide (N.sub.3) radical looses electrons and forms gaseous nitrogen while the oxygen atom picks up the electrons, in the presence of platinum, and forms water with the surplus hydrogen atoms (H.sup.+) present. The measured cell voltage is 5 volts.

Growing community of inventors

Chapel Hill, NC, United States of America

Robert C Bohannon