Boston Scientific Scimed, Inc.

Schneider (usa) Inc.

Other

Medtronic, Inc.

Empi Corp.

Schneider Gmbh

C. R. Bard, Inc.

Boston Scientific Corporation

Richard L. Goodin

Larry Peterson

Robert Burgmeier

Richard Goodin

Joseph Delaney

Richard L Goodin

Joseph T Delaney, Jr

Larry William Peterson

Jan Weber

Lixiao Wang

Ronald A Sahatjian

John Jianhua Chen

Daniel James Horn

Richard Charles Gunderson

Scott Schewe

John Robert Moberg

John B Blix

Jeffrey Chun Wang

Katherine M Prindle

Yiqun Wang

Ismail Guler

Albert C C Chin

Robert N Hamlin

Oleg Stanilevskiy

Cyal Lecy

Robert Clapp

David W Lodin

Joseph Jr Delaney

Isamail Guller

Katherine Prindle

Medical devices such as stents, stent grafts, and balloon catheters include a coating layer applied over a modified exterior surface of the medical device. The modified exterior surface comprises an exterior surface of the medical device subjected to a surface modification that decreases a surface free energy of the exterior surface before application of the coating layer an exterior surface. The coating layer comprises a hydrophobic therapeutic agent and at least one additive. The modified exterior surface may affect the release kinetics of the drug from the device, the crystallinity of the drug layer, the surface morphology of the coating and particle shape, or the particle size of drug of a therapeutic layer in the coating layer. For example, the effects caused by the modified exterior surface may increase the retention time and amount of therapeutic agent in tissue.

Medical device with drug-eluting coating on modified device surface

Systems for delivering medical devices, as well as related methods are described.

Coil shaft

An antimicrobial accessory may include a polymer an antimicrobial mixed in the polymer, and an antioxidant. The antioxidant may include, for example, at least one of citric acid, maltol, kojic acid, malic acid, or vitamin A. In some examples, the antioxidant may include an ascorbate peroxidase in combination with ascorbic acid, a glutathione peroxidase in combination with glutathione, or a superoxide dismutase in combination with a metal such as Ni, Cu, Mn, or Fe. In some examples, the antimicrobial accessory may include at least three polymer layers. For example, the antimicrobial accessory may include a first layer comprising a biodegradable polymer and an antimicrobial. The antimicrobial accessory may further include a sacrificial diffusion layer formed on a surface of the first layer. The sacrificial diffusion layer may include a biodegradable polymer, which may be the same biodegradable polymer as in the first layer or may be a different biodegradable polymer. The antimicrobial accessory may also include a topcoat formed on the sacrificial diffusion layer. The topcoat may include a biodegradable polymer and at least one antioxidant mixed in the biodegradable polymer.

Antioxidants and antimicrobial accessories including antioxidants

An athertome assembly comprises a series of spanning and descending members extended between a segmented base and a cutting surface. This athertome assembly configuration provides both flexibility and structural strength which faciliates the implantation of medical devices.

Cutting blade for medical devices

An athertome assembly comprises a series of spanning and descending members extended between a segmented base and a cutting surface. This athertome assembly configuration provides both flexibility and structural strength which facilitates the implantation of medical devices.

A medical device such as a catheter, stent or balloon, is formed by depositing a radiation curable composition on a form made of ice or wax. The deposited composition may be cured by irradiation, suitably with UV light. Complex structures can be built up if the deposition or curing is achieved imagewise. Compositions which photocure to polyester, polyamide or polyimide may be employed. A particular structure is a balloon for a rapid exchange catheter which has a guide wire lumen passing through the balloon cone walls.

Medical balloons and processes for preparing same

A medical device such as a tube or a balloon including wall structure with multiple layers. The wall structure can distribute stress, resulting in reduced defect propagation and failure.

Multilayer medical device

A medical device in which a melt processed part has different crystallized properties at different locations. The part is formed of a polymer composition by inclusion a of polymer crystallization modifier in the composition making up at least a portion of such part, the amount of the polymer crystallization modifier is varied at different locations on the part in accordance with the desired difference in crystallization behavior.

Medical device with varying physical properties and method for forming same

A catheter for delivering a medical device into a body lumen, and method for preparing said catheter, wherein the catheter comprises an elongate body, at least a portion of which defines a medical device retaining region for retaining a medical device thereon. At least a portion of the medical device retaining region comprises a predetermined pattern of material. The predetermined pattern of material is a photoresist material that may be placed on the outer surface of the catheter to modify at least one physical property of the catheter.

Catheter balloon with improved retention

A catheter for crossing an occluding lesion with an inflatable balloon and dilating the lesion includes an inner tube that defines a longitudinal axis. The balloon includes a distal section that is bonded to the tube's distal end, a working section, and a conically shaped distal transition section connecting the working and distal section. A plurality of rigid ribs are spaced around the circumference of the balloon near the catheter's distal end. Each rib includes a first elongated portion attached to the balloon's distal section and aligned substantially parallel with the longitudinal axis. A second portion extending from the first portion and at an angle thereto is attached to and lies along the surface of the balloon's distal transition section. The plurality of ribs combine to simulate a stiff, tapered surface that can be wedged into the occluding lesion to create a passageway to cross the lesion with the balloon.

Dilatation catheter with enhanced distal end for crossing occluded lesions

A dilatation balloon for use in combination with a catheter device, the balloon having a waist, cone and body portion and having a first layer formed from a first polymeric composition, the balloon having a second layer disposed on at least a portion of the first layer, the second layer formed from a second polymeric composition which is crosslinked on at least a portion of the dilatation balloon, and methods of making and using the same.

Balloons having a crosslinkable layer

A coextrusion employing a tie layer between two layers of different polymer materials. The tie layer is formed in the extrusion melt of a composition comprising one of the two polymer materials and a coupling agent that includes functional groups that are reactive at least with functional groups on the second polymer. The coupling agent may be incorporated into the tie layer material in amounts above 5% by weight.

Adhesion technique for incompatible polymers using modified polymer tie layers

Growing community of inventors

Plymouth, MN, United States of America

Robert Burgmeier