Cordis Corporation

Caliber Therapeutics, Inc.

Cardinal Health Switzerland 515 Gmbh

Cardinal Health Switzerland Gmbh

Kirk L. Johnson

Robert Burgermeister

Mark N. Inderbitzen

Vipul Dave

Darren R Sherman

David W Overaker

William R Baumbach

Ramesh Marrey

Vipul Bhupendra Dave

Matthew E Krever

David Christopher Majercak

Hikmat Hojeibane

Joseph Henry Contiliano

Qiang Zhang

David R Fischell

Robert E Fischell

John Francis Shanley, Iv

Jin S Park

Daniel Olsen

Edwin Alexander Schulting

Prasanna Muralidharan

Ramesh V Marrey

Volker Niermann

Yufu Li

Kirk L Johnson

Thomas Duerig

Ryan R Donovan

Wilhelmus Petrus Van Erp

Richard Dirks

Janet Burpee

Randall James Beyreis

Pallassana V Narayanan

Chao C Chen

Mark N Inderbitzen

Erin Black

Martin B Leon

Theresa Scheuble

I John Khan

Randy Grishaber

Mathew Krever

Randy-David Burce Grishaber

Yuchen Qiu

Randy-David Bruce Grishaber

Chao Chen

Fernando De Caprio

Paul Ferrara

Ricci Dayle Smelser

Yuchen Qui

Brady Jon Hatcher

Fernando Di Caprio

Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for stent deployment, are modified with the addition of a reservoir of dry micelles. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.

Balloon catheter systems for delivery of dry drug delivery vesicles to a vessel in the body

Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.

The present invention relates to tissue-supporting medical devices and drug delivery systems, and more particularly to tubular flexible stents that are implanted within a body lumen of a living animal or human to support the organ, maintain patency and/or deliver drugs or agents. The tubular flexible stent has a cylindrical shape defining a longitudinal axis and includes a helical section having of a plurality of longitudinally oriented strut members and a plurality of circumferentially oriented hinge members connecting circumferentially adjacent strut members to form a band. The band is wrapped about the longitudinal axis in a substantially helical manner to form a plurality of helical windings. At least one connector member extends between longitudinally adjacent helical windings of the band.

Flexible stent design

Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles, disposed at a suitable location within the balloon or catheter. The reservoir may be installed within the angioplasty balloon, within a lumen in communication with the angioplasty balloon, either as a loose or packed powder or as a film coating. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.

A biocompatible material may be configured into any number of implantable medical devices including intraluminal stents. Polymeric materials may be utilized to fabricate any of these devices, including stents. The stents may be balloon expandable or self-expanding. The polymeric materials may include additives such as drugs or other bioactive agents as well as radiopaque agents. By preferential mechanical deformation of the polymer, the polymer chains may be oriented to achieve certain desirable performance characteristics. The stent has a plurality of hoop components interconnected by a plurality of flexible connectors. The hoop components are formed as a continuous series of substantially longitudinally or axially oriented radial strut members and alternating substantially circumferentially oriented radial arc members. The geometry of the struts and arcs is such that when the stent is expanded, it has very high strains within a relatively small region. This strain localization results in what is often referred to as 'hinging', where the hinge is the small region within which the strains are very high.

Balloon expandable bioabsorbable drug eluting stent

This invention concerns expandable intraluminal medical devices for use within a body passageway or duct, wherein the devices exhibit differing degrees of flexibility around the circumference of the device.

Intraluminal medical device having variable axial flexibility about the circumference of the device

A biocompatible material may be configured into any number of implantable medical devices including intraluminal stents. Polymeric materials may be utilized to fabricate any of these devices, including stents. The stents may be balloon expandable or self-expanding. The polymeric materials may include additives such as drugs or other bioactive agents as well as radiopaque agents. By preferential mechanical deformation of the polymer, the polymer chains may be oriented to achieve certain desirable performance characteristics. The stent has a plurality of hoop components interconnected by at least one flexible connector. The hoop components are formed as a continuous series of alternating substantially longitudinally oriented strut members and connector junction struts, whereas the longitudinal strut is connected to the connector junction strut by alternating substantially circumferentially oriented arc members.

Balloon expandable bioabsorbable drug eluting flexible stent

The present invention relates to a drug-containing polymeric composition comprising at least one therapeutic agent encapsulated in at least one biocompatible polymer, wherein at least a portion of the therapeutic agent in this polymeric composition is crystalline. The at least one biocompatible polymer may form a substantially continuous polymeric matrix with the at least one therapeutic agent encapsulated therein. Alternatively, the at least one biocompatible polymer may form polymeric particles with the at least one therapeutic agent encapsulated therein.

Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same

This invention relates generally to expandable intraluminal medical devices for use within a body passageway or duct, and more particularly to an optimized stent having asymmetrical strut and loop members, wherein at least one pair adjacent radial strut members have unequal axial lengths.

Intraluminal medical device having asymetrical members of unequal length

The present disclosure concerns a delivery system for delivering a medically useful payload through the vasculature to a site of interest in the patient's body. The medically useful payload may be a therapeutic device, such as a stent, and it may be a diagnostic tool, such as an imaging device. Owing to its structural attributes, the presently-inventive delivery system is well suited for carrying medical payload to and through vessel curvature and to branched regions (i.e., bifurcations) in same. Also, the device is well-suited to traveling through a vessel over a guiding element, such as a guidewire, which itself exhibits curvature.

Medical delivery system for delivery of a medically useful payload

Growing community of inventors

Bridgewater, NJ, United States of America

Robert Burgermeister