Beckman Coulter, Inc.

Nanogen, Inc.

Gamida for Life B.v.

Robert Bruce Wallace

Ray R Radtkey

David Canter

Karen Menge

Lance C Held

M Parameswara Reddy

Kurt L Brillhart

An assay system and methods are described where patient samples containing genomic DNA are analyzed for the presence of known genetic polymorphisms using a universal reporter strategy. In a preferred embodiment, the amplified DNA is localized at test sites in an array of sites on a microchip followed by a series of hybridization reactions that screen for the presence of a single mutation from among a number of mutations, and allow the identification of specific mutations. In addition to universal reporters, the assay may use blockers and discriminators for screening and identification of known polymorphisms.

Methods and apparatus for screening and detecting multiple genetic mutations

Methods for determining the presence of an analyte in a sample are disclosed, in which a capture agent is bound to the analyte at a first epitope and a detection agent is bound at a second epitope, and in which the detection agent includes an oligonucleotide to which a labeled, complementary oligonucleotide can be hybridized.

Labeled complementary oligonucleotides to detect oligonucleotide-linked ligands

Growing community of inventors

Escondido, CA, United States of America

Robert Bruce Wallace