Merck Sharp + Dohme Corp.

Sagres Discovery, Inc.

Novartis Vaccines & Diagnostics, Gmbh

Curis, Inc.

Robert Booher

Albert Lai

Peter Strack

Joseph H Phillips

Michael Rowe

Christin Tse

Venkataraman Sriram

Edward Moler

Xie Xu

Guoying Yu

Abdallah Fanidi

Peter Richard Strack

The present invention provides methods of treating hematological disorders and solid malignant tumors, using substituted indazole compounds and pharmaceutically acceptable salts thereof. The compounds inhibit IRAK4 and BCL-2 kinases.

Compounds and compositions for treating hematological disorders

A method for the treatment of cancer by administering a therapeutically effective amount of a cyclin-dependent kinase (CDK) inhibitor with a therapeutically effective amount of a B cell chronic lymphocytic leukemia/lymphoma 2 inhibitor ('B Cell CLL/Lymphoma 2', or 'BCL-2'). Administration of the CDK inhibitor and BCL-2 inhibitor can be simultaneous, successive or separate.

Method for treating cancer

The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and the CDK inhibitor dincaciclib, and the use of the combination therapies for the treatment of cancer, and in particular for treating cancers that express PD-L1.

Treating cancer with a combination of a PD-1 antagonist and dinaciclib

The present invention relates to novel sequences for use in detection, diagnosis and treatment of diseases, including cancer. The invention provides novel splice products of human DKKL-1 gene. The present invention provides methods of using polynucleotides having the novel splice products of the human DKKL-1 sequences, their corresponding gene products and modulators of the DKKL-1 splice products for the detection, diagnosis, prevention and/or treatment of associated cancers.

DKKL-1 splice product modulators for cancer diagnosis and therapy

This invention is in the field of cancer-related genes. Specifically it relates to methods for detecting cancer or the likelihood of developing cancer based on the presence or absence of the SEM A4D gene or proteins encoded by this gene. The invention also provides methods and molecules for upregulating or downregulating the SEMA4D gene.

SEMA4D in cancer diagnosis, detection and treatment

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Davis, CA, United States of America

Robert Booher