Bayer Aktiengesellschaft

Robert Bierling

Gerhard D Wolf

Bruno Bomer

Hans-Joachim Kabbe

Gunther Nischk

Ernst Truscheit

Siegfried Petersen

Horst D Schlumberger

Herbert F Oettgen

Ghanem Atassi

Hans-Egon Kunzel

Dieter Steinhoff

A carcinostatic composition useful in inhibiting the growth of colon and/or rectal tumors comprising 8-amino-12-oxo-10, 12-dihydroindolo [1,2-b]-quinazoline of the formula: ##STR1##

Carcinostatic agent

The invention relates to pharmaceutical compositions containing, as an active ingredient, a water-soluble polyester or polycarbonate based on one or more polyetherglycols of Formula (I) as defined in the specification. Also included in the invention is the use of said compositions for their tumor-inhibiting action.

Agents having a tumor-inhibiting action and their use

A water soluble immunopotentiating agent is derived from yeast cell wall material, including mechanically disrupted yeast cell walls, proteolyzed yeast cell wall material and carbohydrate-protein complexes found in yeast cell wall material, through extraction with a water-phenol mixture. The water soluble agent is isolated from the water phase and can be further purified, as through dialysis, to remover low molecular weight components.

Process for the preparation of immunopotentiating agents from components

2-Phenyl-4(3H)-quinazolones bearing a urethane or thiourethane group on the 2-phenyl substituent, a second urethane or thiourethane group on the benzo ring of the quinazolone nucleus and an alkyl, cycloalkyl or phenyl group in the 3-position are prepared by treating the corresponding bis-amino compound with an acid derivative or the corresponding bis(isocyanate) or bis(isothiocyanate) with an alcohol. The compounds, of which 2-[3'-(methoxycarbonylamino)-phenyl]-3-phenyl-6-methoxycarbonylamino-4-(3H )-quinazolone is a typical embodiment, are cytostatic agents.

Urethane derivatives of 2-phenyl-4(3H)-quinazolones

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Wuppertal, Germany

Robert Bierling