Miles Laboratories, Inc.

Miles Inc.

Other

Robert Bauer

Thomas A Magers

Ronald A Lewis, Ii

Myron C Rapkin

Michael A Van Lente

Glenn E Gibson

John A Cattell

Carol J Allen

Chauncey Orvis Rupe

Test devices and methods are provided for detection of feline lower urinary tract disease. The test devices comprise a matrix impregnated with a color indicator and a stabilizer wherein the indicator remains stable when exposed to ambient conditions and wherein a positive color response remains stable for a sufficient time for the color response to be observed. The test devices may be provided for use in combination with conventional cat box filler.

Preparation and method for cat box filler additive capable of detecting feline lower urinary tract disease (FLUTD)

A golf swing training apparatus consisting of a base; a club guide ring; left, right, and rear hinge shafts; left, right, and rear hinge sleeves, the left, right, and rear hinge shafts extending through the left, right, and rear hinge sleeves so that the left and right ends of the left, right, and rear hinge shafts extend leftwardly and rightwardly from the left and right ends of the left, right, and rear hinge sleeves. Each of the left and right ends of the left, right, and rear hinge shafts are attached to the base or making up a part of the base. Left, right, and rear slip joints are provided for attaching the club guide ring to the left, right, and rear hinge sleeves. The rear slip joint consists of an alternately extendable and retractable shaft for, upon alternate extension and retraction, alternately pivoting and counter-pivoting the club guide ring about the left and right hinge shafts.

Golf swing training apparatus

A method, composition and test device for the semiquantitative determination of specific gravity of a test sample are disclosed. The method utilizes a reagent composition capable of producing a detectable and measurable response that correlates to the concentration of cations, and therefore the specific gravity, of the test sample. The reagent composition comprises: a) a polyvalent metal ion having a valence of at least two, like mercuric ion or calcium ion; b) an indicator capable of interacting with the polyvalent metal ion to provide a polyvalent metal ion-indicator complex having a first color; c) a buffer; and d) a suitable carrier. The reagent composition is used in a wet phase specific gravity assay or is incorporated into a carrier matrix, like filter paper, to provide a test pad useful in a dry phase specific gravity assay of a test sample, such as urine.

Method, composition and device for the semiquantitative determination of

A method, composition and test device for the semiquantitative determination of specific gravity of a test sample are disclosed. The method utilizes a reagent composition capable of producing a detectable and measurable response that correlates to the concentration of cations, and therefore the specific gravity, of the test sample. The reagent composition, comprises: a) a complexing agent, like a polyelectrolyte, an ion exchange material or a chelating agent, such as a copolymer of maleic acid and methyl vinyl ether; b) a polyvalent metal ion having a valence of at least two, like ferrous ion or cobaltous ion; c) an indicator capable of interacting with the polyvalent metal ion to provide a color transition, like calmagite or gallocyanine; and d) a suitable carrier. The reagent composition is used in a wet phase specific gravity assay or is incorporated into a carrier matrix, like filter paper, to provide a test pad useful in a dry phase specific gravity assay of a test sample, such as urine.

Composition for the semiquantitative determination of specific gravity

The present invention provides a stable, convenient solid state test device for the determination of ethanol in an aqueous test sample, a method for its preparation and a method for its use. The use of carrier matrix incorporated with alcohol oxidase, a peroxidatively active substance and a suitable chromogenic indicator for the determination of ethanol in aqueous samples such as body fluid samples (e.g., serum, urine or saliva) is part of the invention. The invention provides a method of incorporating the enzyme alcohol oxidase and a peroxidatively active substance into a carrier matrix with a chromogenic indicator system capable of providing a detectable response to the presence of at least 100 mg/dL ethanol in less than about 5 minutes. The method involves either (a) the use of a specialized incorporation procedure or (b) the addition of an azide to the test device. Either method overcomes the 'false positive' problem seen when solution assay reagents are incorporated at the increased concentrations necessary to provide a test device sensitive to the at least 100 mg/dL ethanol.

Enzymatic ethanol test

An improved method for visually comparing the results of colorimetric analytical tests to a color reference standard, enabling substantially improved quantitation to be achieved for such tests, is disclosed. Also disclosed is improved apparatus, in the form of an improved color comparision reference standard, which is useful in the method. In one embodiment, the standard can comprise a plurality of colored reference areas of differing hues corresponding to discrete reference values and to which a colored response area of a colorimetric analytical test can be compared to determine the reference value most closely related to the hue of the colored response area, and a background area against which the colored reference areas are displayed. The background area has a luminance (L*) value of from about 15 to about 80, and the luminance (L*) value of any portion of the background area is within about 30 of the average luminance (L*) value of any two or more adjacent ones of the colored reference areas which are displayed against the portion of the background area.

Color comparison reference standard and method for using same

A composition, test device and method for detecting the presence and/or determining concentration of glucose in a liquid test sample are disclosed. The composition is capable of determining glucose concentration over a broad range, e.g. 0 to about 5,000 milligrams (mg) of glucose per deciliter (dl) of test sample. Moreover, the composition is resistant to interference from the presence of ascorbate in the sample. The composition comprises glucose oxidase, peroxidase and, as an indicator capable of producing a detectable response in the presence of peroxidase and H.sub.2 O.sub.2, a mixture of two compounds. One has the structure ##STR1## and the other has the structure ##STR2## in which R, same of different, is H or lower alkyl, R' is aryl and R' is lower alkyl.

Ascorbate-resistant broad range glucose test composition, test device

The present invention involves an improved test system for the determination of glucose in aqueous fluids of the type which comprises glucose oxidase, a peroxidatively active substance and chromogen. The improvement involves the use of m-anisidine as a chromogen which permits the semi-quantitative determination of glucose at higher concentrations than is possible with previously used chromogens.

System for the determination of glucose in fluids

A method and test device for determining the glucose concentration in a test sample containing from 1/2 to 10 percent glucose are disclosed. The method and test device involve impregnating the carrier with an enzymatic testing composition which includes glucose oxidase, peroxidase and a chromogen. The carrier is subsequently impregnated with from 0.5 to 1.5 percent by weight polystyrene. Contact of the carrier with a glucose-containing test sample produces a detectable response whereby the glucose concentration can be determined.

Method and device for detecting glucose concentration

A method and test device for determining the glucose concentration in a test sample containing from 1/2 to 10 percent glucose are disclosed. The method and test device involve impregnating the carrier with an enzymatic testing composition which includes glucose oxidase, peroxidase and a chromogen. The carrier is subsequently impregnated with from 0.5 to 1.5 percent by weight polystyrene. Contact of the carrier with a glucose-containing test sample produces a detachable response whereby the glucose concentration can be determined.

Device for detecting glucose concentration

A method and test device for determining the glucose concentration in a test sample containing from 1/2 to 5 percent glucose. The method and test device involve incorporating urea-formaldehyde resin in a carrier matrix and subsequently impregnating the carrier with an enzymatic testing composition which includes glucose oxidase, a peroxidatively-active compound and a chromogen. Contact of the carrier with a glucose-containing test sample produces a detectable response whereby the glucose concentration can be determined.

A test device for detecting bilirubin in serum is provided which comprises a carrier and, incorporated therewith, a composition comprising a diazonium salt, p-toluenesulfonic acid and dyphylline. The test device is free of the undesirable characteristic of nonuniformity of color development when reacted with a test sample. Uniform color development provides a more accurate and reliable quantitation of serum bilirubin. A method of making and a method of using the device are likewise disclosed.

Device for detecting serum bilirubin

A method, device and test reagent for detecting free available chlorine in aqueous fluids which utilizes as an indicator substance azine compounds of the formula: ##STR1## where R and R' are hydroxy or amino substituents and X, X', Y and Y' are hydrogen, hydroxy, methyl or methoxy substituents and may be the same or different. Preferably such test reagents are incorporated with a carrier member or with a wicking device for concentrating the aqueous fluid being tested in the area of the test reagent.

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Bristol, IN, United States of America

Robert Bauer