Institut National De La Sante Et De La Recherche Medicale

Centre National De La Recherche Scientifique

Université Nice Sophia Antipolis

Institut Gustave Roussy

Universite Sophia Nice Antipolis

Inserm (Institut National De La Sante Et De La Recherche Medicale)

Université Cote D'azur

Inserm

Robert Ballotti

Rachid Benhida

Stephane Rocchi

Cyril Ronco

Maria Duca

Jean-Patrick Joly

Corine Bertolotto

Brigitte Bressac De Paillerets

Antoine Millet

Mahaut De Lichy

Fabienne Lesueur

Michael Cerezo

Magali Plaisant

Stéphane Rocchi

The present invention relates to compound of general formula (I) Ris selected from H, aryl and alkyl, Ris selected from H, alkyl, aryl and CO&#x2014;R; Ris selected from H, halogen, alkyl, alkenyl, alkynyl, aryl, NHR, NRR, ORand SR; Ris selected from (C-C) alkyl, (C-C) alkenyl, (C-C) alkynyl and (C-C) aryl, Rrepresents H, R, aryl, OH, OR, O-aryl, SH, SR, S-aryl, CN, NO, CF, COOR, SONRR, CONRR, NH, NHR, NH-aryl, NRR, NHCORor aminoacyl; Ris alkyl optionally substituted with halogen, OH, SH, NH, O-alkyl, S-alkyl, NH-alkyl or NH-di(alkyl); Rand Ridentical or different are H or alkyl optionally substituted with halogen, OH, SH, NH, O-alkyl, S-alkyl, NH-alkyl or NH-di (alkyl), their pharmaceutically acceptable salts and/or isomers, tautomers, solvates or isotopic variations thereof. The compounds are useful for the treatment of cancers. 

Substituted hydrophobic benzene sulfonamide thiazole compounds for use in treating cancer

The present invention relates to compound of general formula (1) wherein Rrepresents C-Caryl comprising one or two fused rings, wherein from 2 to 5 carbon atoms may be replaced with a heteroatom selected from O, S and NR, and eventually substituted with from 5 to 11 substituents selected from R, halo, CN, NO, CF, OCF, COOR, OCOR, SONRR, CONRR, NRR, NRCOR, (CH)&#x2014;NRR, (CH)&#x2014;ORand (CH)SR, as well as, if appropriate, their pharmaceutically acceptable salts and/or isomers, tautomers, solvates or isotopic variations thereof. The compounds are useful for the treatment of cancers. 

Benzene sulfonamide thiazole compounds

The present invention relates to a mutant of MITF which is useful as a marker for predisposition to the development of cancer and to uses thereof in diagnosis and preventive treatments, sumoylation being reduced or absent in this mutant.

MITF as a marker for predisposition to cancer

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Nice, France

Robert Ballotti