University of Pennsylvania

Other

The Children's Hospital of Philadelphia

Robert B Wilson

Yongping Wang

Donna Mary Huryn

Maria Grazia Cotticelli

Amos Smith

Phillip A Benedetti

Jason E Melvin

Shujuan Xia

John M Klein

Steven Maitland Cochran

Taehee Lee

Roberto Forestieri

Maria Grazia Cotticell

John W Tobias

Avinash Kaur

The invention relates to compounds of Formula I or Formula II: to compositions comprising such compounds, and to methods of use thereof for treating neurodegenerative disorders, such as Friedreich ataxia.

Oleic acid derivatives as treatments for Friedreich ataxia and inhibitors of ferroptosis

The invention provides p38 MAPK inhibitors that compensate for a frataxin deficiency or mutation and methods of using the same (e.g., to treat Friedreich's ataxia).

P38 map kinase inhibitors for treating Friedreich's ataxia

This invention provides sets and libraries of short hairpin ribonucleic acid (shRNA) molecules comprising a double-stranded region of random sequence containing random mismatches, methods of generating same, sets and libraries of expression vectors for same, methods of generating same, and methods for identifying an RNA therapeutic or RNA molecule that has an ability to affect a biological parameter, for identifying a drug target for a disease or disorder of interest, and for identifying a variant of an RNA molecule that has an altered ability to affect a biological parameter of interest.

Random RNA libraries, methods of generating same, and screening methods utilizing same

Methods for improving mitochondrial function, decreasing iron accumulation, and/or decreasing oxidative stress by exposing cells or treating a subject to compounds or compositions of the general formula are described that are beneficial in treating, for example, diseases and conditions such as Friedreich's ataxia, normal aging, and various neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Furthermore, such compounds are useful as probes for identifying defects in mitochondrial metabolism, mitochondrial iron accumulation, cellular stress among other mitochondrial diseases and helping to identify compounds active in overcoming such defects.

Small molecule activators of mitochondrial function

This invention provides expression vectors for a ribonucleic acid (RNA) molecule comprising a double-stranded region of random sequence, sets and libraries of same, methods of generating same, and methods for identifying an RNA therapeutic or RNA molecule that has an ability to affect a biological parameter, for identifying a drug target for a disease or disorder of interest, and for identifying a variant of an RNA molecule that has an altered ability to affect a biological parameter of interest.

Random RNAi libraries, methods of generating same, and screening methods utilizing same

Methods for improving mitochondrial function, decreasing iron accumulation, and/or decreasing oxidative stress by exposing cells or treating a subject to compounds or compositions of the general formula (I) are described that are beneficial in treating, for example, diseases and conditions such as Friedreich's ataxia, normal aging, and various neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Furthermore, such compounds are useful as probes for identifying defects in mitochondrial metabolism, mitochondrial iron accumulation, cellular stress among other mitochondrial diseases and helping to identify compounds active in overcoming such defects. 

A bullet-proof or similar protective garment incorporates therewithin segmented panels. The panels are employed to resist penetration of a bullet or other projectile. The panels are configured such that they are flexible or hinged under ordinary conditions, but rigid upon projectile impact. The hinging is achieved by the disposition of the segments of the panel in relationship to the adjacent segments.

Energy impact dissolution and trauma reduction device

A mechanism for receiving elongated articles such as dowel pins, etc., from a bulk source is disclosed which separates the pins and positions them for ejection and insertion by a ram driven driver tool. The mechanism includes a rotary feed cylinder having a plurality of pin receiving chambers extending in directions tending to converge and arranged circumferentially about the feed cylinder axis. The feed cylinder is adapted to receive pins into each chamber via an inlet from the bulk source, while upon rotation about its axis the feed cylinder repositions the pins to be horizontal in the ejection position so to be able to be advanced out of the chamber by means of the driver tool. Rotation and positioning of the feed cylinder is produced by a unique indexing arrangement operated by the driver tool ram, including a ratchet wheel drivingly connected to rotate with the feed cylinder. The ratchet wheel is engaged by an indexing pawl which is in turn oscillated to a cocked position by the driver tool ram and adapted to incrementally advance the ratchet wheel with each stroke of the mechanism upon withdrawal of the driver tool after ejection of an article from a chamber.

Growing community of inventors

Wynnewood, PA, United States of America

Robert B Wilson