Other

Akzona Incorporated

Robert B Polak

Craig R Hof

Roy A Ulin

A disposable container/dispenser assembly for the extended storage and direct intravenous administration of a medicament includes a syringe barrel defining a main chamber for containing a liquid, the barrel including an upper opening in communication with the main chamber; an auxiliary barrel defining an auxiliary chamber for containing a drug to be mixed with the liquid, the auxiliary barrel including second and third spaced and opposing openings in communication with the auxiliary chamber; a first impermeable membrane for sealing the first opening of the main body; a second impermeable membrane for sealing the second opening of the auxiliary body; the first and second openings being in line with each other when the auxiliary body is connected with the main body; a third impermeable membrane secured to the auxiliary body for covering and sealing the third opening; and a plunger slidably positioned outside of the auxiliary body for rupturing the first through third membranes.

Medicament container/dispenser assembly

A medicament container/dispenser assembly includes a substantially non-collapsible main body defining a chamber for containing the medicament in liquid form, the main body having an upper portion and a lower portion; an opening formed in the upper portion; a liquid impervious, gas permeable membrane secured to the upper portion of the main body in sealing relation to the opening; a rupturable exit port formed in the lower portion of the main body. The assembly may also include a second opening formed in the upper portion of the main body in spaced relation to the first-mentioned opening and an elastomeric, puncturable, sealing material secured to the upper portion of the main body in sealing relation to the second opening. In a further embodiment, a conduit may be positioned adjacent the membrane at the upper section of the main body, and may contain a blower for supplying forced air to the membrane through the conduit. A sensing device for sensing flow of the liquid medicament from the exit port and for controlling the blower in response thereto may be associated with the blower, in order to selectively activate the blower to maintain a substantially constant flow of medicament from the exit port.

A new and useful particulate magnesium phosphate product (MGP) and method of use therefor are disclosed for removing ammonia from aqueous solutions, e.g., recirculating dialysate solutions and intragastrointestinal fluids as may result from the hydrolysis of urea. This particulate magnesium phosphate product (MGP) acts as a remarkably effective scavenger wherein under equilibrium conditions only about six (6) grams of the novel product are required to bind the ammonia (more exactly, ammonium ions) liberated from one (1) gram of the urea, a result far superior to traditional zirconium phosphate (ZP) prior art materials which under ideal conditions require about 17-20 grams of ZP per gram of urea. The novel particulate magnesium phosphate product can be exploited in one embodiment as a replacement for the older ZP materials used to remove ammonia produced by enzymatic hydrolysis of urea in recirculating dialysis systems utilizing disposable cartridges. In another embodiment, in a new encapsulated product (comprising a water-insoluble, membranous wall, permeable to urea and/or ammonia and water, while impermeable to urease enzyme, wherein the wall surrounds a core of urease and the novel particulate magnesium phosphate product) is disclosed, which can also be used as an in vivo or in vitro scavenger. This particulate MGP product can also be used for the removal of ammonium ions either produced by enzymatic or non-enzymatic hydrolysis of urea or proteins or amino acids or available as NH.sub.4.sup.+ from its native source. A new method is also disclosed for the preparation of the novel particulate magnesium phosphate product.

Ammonia scavenger

A new and useful all plastic disposable thermometer is disclosed, which dispenses with the prior art employment of an aluminum or other metal-based substrate. The novel thermometer can either be employed with opaque indicator means or with heat-sensitive compositions of matter that change color with a change in phase, such as those enumerated in copending application Ser. No. 946,935, filed Sept. 28, 1978, now U.S. Pat. No. 4,232,552.

Growing community of inventors

Asheville, NC, United States of America

Robert B Polak