Pharmacia & Upjohn Company

The Upjohn Co.

Robert B McCall

Martin Durham Meglasson

Robert Clyde Marshall

David W Robertson

Thomas M Ashley

Arthur Glenn Romero

Chiu-Hong Lin

Michael D Ennis

Susanne R Haadsma-Svensson

William H Darlington

The present invention is a method of treating sexual disturbances in humans and inducing mating in non-human mammals using the compounds of formula (A)in a dosage range where the sexually therapeutic amount is from about 0.2 thru 8 mg/person/dose and where the sexually mating amount is from about 0.003 thru 0.2 mg/kg/dose.

Method of treating sexual disturbances

The present invention provides for methods for the treatment of fibromyalgia syndrome or chronic fatigue syndrome by the administration of cabergoline-type compounds or a salt of said compound.

Compounds for treating fibromyalgia and chronic fatigue syndrome

The present invention provides for methods for the treatment of fibromyalgia syndrome or chronic fatigue syndrome by the administration of heterocyclic amine-type compounds or a salt of any said compound.

Treating fibromyalgia and chronic fatigue syndrome

This invention is therapeutically useful tetralins and pharmaceutically acceptable acid addition salts thereof of the formula I: ##STR1## wherein X is --(CH.sub.2).sub.n -- or --C(R.sub.1)(H)--; R is C.sub.1 -C.sub.8 alkyl; and R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of hydrogen, C.sub.1 -C.sub.8 alkyl, C.sub.2 -C.sub.8 alkenyl, C.sub.2 -C.sub.8) alkynyl, aryl and benzyl. These compounds are useful to treat central nervous system disorders and are unexpectedly resistant to metabolism by the liver and have superior oral plasma bioavailability.

Carboxamido-(1,2N)-carbocyclic-2-aminotetralin derivatives

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Kalamazoo, MI, United States of America

Robert B McCall