Mayo Foundation for Medical Education and Research

Other

Abbott Molecular Inc.

Vysis, Inc.

Decipher Biosciences, Inc.

Veracyte Sd, Inc.

Genomedx Biosciences Inc.

Robert B Jenkins

Irina A Sokolova

Steven A Seelig

Walter E King

Kevin C Halling

Geoffry L Curran

Gobinda Sarkar

Elai Davicioni

Joseph F Poduslo

Nicholas Erho

Val J Lowe

Ismael A Vergara Correa

Anamaria Crisan

Mercedeh Ghadessi

George G Klee

Walter King

Christine Buerki

S Keith Anderson

Tohru Nakagawa

Eric W Mahlum

Thomas M Kollmeyer

Erik W Mahlum

Junqi Qian

Karla V Ballman

Kazunari Sato

Eric J Bergstralh

Nicholas George Erho

Bruce W Morlan

In some embodiments, a machine learning model may be accessed and used to generate a likelihood score related to a condition. In some embodiments, pre-computed vectors may be derived from a training dataset used to build the machine learning model, and the pre-computed vectors may be used to generate processed data from target data derived from a target sample. The machine learning model may then be used on the processed data to generate the likelihood score related to the condition. As an example, subsets of the training dataset may be randomly selected, and the pre-computed vectors may be derived from the randomly-selected subsets of the training dataset. The pre-computed vectors may be applied to the target data to generate the processed data. In one use case, for example, the target data may be normalized using the pre-computed vectors.

Systems and methods for preprocessing target data and generating predictions using a machine learning model

Disclosed herein, in certain instances, are methods, systems and kits for the diagnosis, prognosis and determination of cancer progression of a cancer in a subject. Further disclosed herein, in certain instances, are methods, systems and kits for determining the treatment modality of a cancer in a subject. The methods, systems and kits comprise expression-based analysis of biomarkers. Further disclosed herein, in certain instances, are probe sets for use in assessing a cancer status in a subject.

Cancer diagnostics using biomarkers

This document provides methods and materials related to assessing male mammals (e.g., humans) with prostate cancer. For example, methods and materials for predicting (1) which patients, at the time of PSA reoccurrence, will later develop systemic disease, (2) which patients, at the time of retropubic radial prostatectomy, will later develop systemic disease, and (3) which patients, at the time of systemic disease, will later die from prostate cancer are provided.

Biomarker panels for predicting prostate cancer outcomes

The peptides described herein can function as carrier peptides. These peptides can associate with (e.g., non-covalently bind) biologically active molecules or imaging agents to transport the biologically active molecules or imaging across the blood-brain barrier. In some cases, such transport may increase the effectiveness of the biological molecules or imaging agents.

Peptide-mediated non-covalent delivery of active agents across the blood-brain barrier

Provided herein are materials and methods for delivering immunoglobulins (e.g. therapeutic immunoglobulins) across the blood-brain barrier.

Peptide-mediated delivery of immunoglobulins across the blood-brain barrier

Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if aneusomic cells are present in a selected subset of cells obtained from the biological sample are described. A set of chromosomal probes and kits for detecting cancer that include sets of chromosomal probes, are also described.

Method and probe set for detecting cancer

A fastener system including a threaded fastener having a slot formed in the fastener head. Facets are formed in the slot walls, each facet having an angle of less than ninety degrees with respect to the base of the slot such that the slot has a variable width and at least a portion of the width of the base is greater than the width of the opening of the slot. A driver bit includes a blade configured to be inserted into the slot of the fastener. At least a portion of the free end of the blade has an increased width such that the blade is locked within the slot of the fastener when torque is applied to the driver bit.

High speed, high torque screw fasteners and drive systems

An Interactive Submergible Tow Craft pulled by a powered vessel such as water skies and tubes for tubing. A user seated in the craft has control over a pair of rudders which rotate either upward or downward causing the craft to submerge in water or breach the craft while being pulled through the water. The craft may be broken down into smaller parts for customization, maintenance or easy transport.

Interactive submergible tow craft

An automated water control system for a shower or bath that provides means for automated controls that give the user management of both water temperature and water flow as well as historical statistics on consumption.

Thermostatic water mixing unit

This document provides methods and materials related to detecting t(1;19) as well as methods and materials for identifying or assessing cancer within a mammal (e.g., a human). For example, methods for assessing the aggressiveness of a low-grade glioma in a human are provided.

Detecting t(1;19)

Growing community of inventors

Rochester, MN, United States of America

Robert B Jenkins