Eli Lilly and Company

Robert B Hermann

Nicholas J Bach

Robert D Dillard

Susan Elizabeth Draheim

Richard Walter Schevitz

A class of novel 1H-indole-3-acetamides is disclosed together with the use of such indole compounds for inhibiting sPLA,mediated release of fatty acids for treatment of conditions such as septic shock.

1H-indole-3-acetamide sPLA2 inhibitors

A class of novel 1-indole-3-acetamides represented by the formula; ##STR1## is disclosed together with the use of such indole compounds for inhibiting sPLA.sub.2 mediated release of fatty acids.

1H-indole-3-acetamide sPLA.sub.2 inhibitors

A class of novel 1H-indole-3-acetic acid hydrazides is disclosed together with the use of such indole compounds for inhibiting sPLA.sub.2 mediated release of fatty acids (e.g., arachidonic acid) for treatment of conditions such as septic shock.

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Indianapolis, IN, United States of America

Robert B Hermann