Heska Corporation

Colorado State University Research Foundation

Other

Robert B Grieve

Glenn R Frank

Cynthia Ann Tripp

Shirley Wu Hunter

Keith E Rushlow

Nancy Wisnewski

Gary L Stiegler

Patrick J Gaines

Donald L Wassom

Murray E Selkirk

Michael R McNeil

Gary M Silver

Marcia Mika-Grieve

James P Porter

Miles Yamanaka

Beverly Dale

Ann Arfsten

Jennifer K Richer

Roy R Mondesire

Cheng Xiong

Andrew Heath

The present invention relates to isolated parasitic helminth nucleic acid sequences capable of hybridizing, under stringent conditions, to at least a portion ofnucleic acid sequence p4 and/or to at least a portion ofnucleic acid sequence p22U; to isolated parasitic helminth proteins that are encoded by such parasitic helminth nucleic acid sequences and that are capable of selectively binding to at least one component of immune serum capable of inhibiting helminth development; and to antibodies raised against such isolated parasitic helminth proteins. The present invention also relates to therapeutic compositions comprising such isolated nucleic acid sequences, proteins and/or antibodies. The present invention also includes methods to produce and use such nucleic acids, proteins, antibodies and therapeutic compositions capable of protecting animals from parasitic helminth infection and, particularly, from heartworm, infection.

Filariid anti-P22U antibodies

The present invention relates to parasite astacin metalloendopeptidase proteins, nucleic acid molecules having sequences that encode such proteins, antibodies raised against such proteins and compounds that can inhibit the activities of parasite astacin metalloendopeptidases. The present invention also includes methods to obtain such nucleic acid molecules, proteins, antibodies and inhibitors. The present invention also includes therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and inhibitors as well as their use to protect animals from disease caused by parasites, such as heartworm infection.

Anti-parasite astacin metalloendopeptidase antibodies

The present invention relates to parasitic helminth PLA2 proteins; to parasitic helminth PLA2 nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit parasitic helminth phospholipase A activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.

Compositions of parasitic helminth PLA2 nucleic acid molecules and uses thereof

The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, L3 larval cysteine protease nucleic acid molecules and L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.

Filariid nematode cysteine protease proteins, and uses thereof

The present invention includes a method to detect infection in a host animal using a Di33 protein to detect anti- Di33 antibodies in a bodily fluid of the animal. Also included is a method to detect infection in a host animal using a anti-Di33 protein to detect Di33 proteins in a bodily fluid of the animal. The present invention also relates to detection kits that include either a Di33 protein or an anti-Di33 antibody; such kits also include a composition to detect an immunocomplex between the anti-Di33 antibody and Di33 protein. The present invention also includes Di33 proteins, nucleic acid molecules encoding such proteins, as well as recombinant molecules and recombinant cells comprising such nucleic acid molecules, and anti-Di33 antibodies. Also included are methods to produce such proteins, nucleic acid molecules and antibodies.

Method to detect Dirofilaria immitis infection

Filariid nematode cysteine protease nucleic acid molecules and uses thereof

Parasite astacin metalloendopeptidase nucleic acid molecules and uses thereof

Parasite astacin metalloendopeptidase proteins

The present invention relates to flea serine protease proteins, aminopeptidase proteins and flea cysteine protease proteins; to flea serine protease, aminopeptidase and cysteine protease nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease, aminopeptidase and/or cysteine protease activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.

Flea serine protease nucleic acid molecules and uses thereof

Flea leucine aminopeptidase nucleic acid molecules and uses thereof

Flea leucine aminopeptidase proteins and uses thereof

Flea protease proteins and uses thereof

The present invention relates to flea serine protease and aminopeptidase proteins; to flea serine protease and aminopeptidase nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease and/or aminopeptidase activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.

Flea protease proteins

Methods of eliciting an antibody response using flea protease proteins

Flea aminopeptidase proteins and uses thereof

Growing community of inventors

Fort Collins, CO, United States of America

Robert B Grieve