Dow Global Technolgoies LLC

Nutrition & Biosciences USA 1, LLC

Robert B Appell

Oliver Petermann

Matthias Sprehe

David L Malotky

Christopher John Tucker

Edward D Daugs

Matthias Knarr

Meinolf Brackhagen

Roland Adden

Robert Thomas Nilsson

Susan L Jordan

True L Rogers

Jorg Theuerkauf

Peter E Pierini

Joseph L Weir

Roja Ergun

A process includes: (a) providing an initial cellulose ether powder containing 0.5 to 10 weight-percent water based on total cellulose ether powder weight; (b) heating the initial cellulose ether powder to a temperature in a range of 30 to 130 degrees Celsius; (c) before, during and/or after heating in step (b), adding solid base to the cellulose ether powder and mixing with the initial cellulose ether powder to form a cellulose ether/base mixture; (d) adding volatile acid to the cellulose ether/base mixture and mixing; and (e) allowing the volatile acid to hydrolyze the initial cellulose ether to form a final cellulose ether having a lower viscosity than the initial cellulose ether.

Method for controlled preparation of low molecular weight cellulose ether

Provided is a process for reducing the size of ethylcellulose polymer particles comprising Also provided is a dispersion made by such a process.

Size reduction of ethylcellulose polymer particles

An esterified cellulose ether comprising aliphatic monovalent acyl groups and groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOH, R being a divalent hydrocarbon group, has the following properties: i) the degree of neutralization of the groups &#x2014;C(O)&#x2014;R&#x2014;COOH is not more than 0.4, ii) the total degree of ester substitution is from 0.10 to 0.70, and iii) the esterified cellulose ether has a solubility in water of at least 2.0 weight percent at 2 C.

Water-soluble esterified cellulose ethers having a low degree of neutralization

A process for producing an esterified cellulose ether can be efficiently be produced by reacting a moist cellulose ether having a water content of at least 10 percent, based on the weight of the moist cellulose ether, with an aliphatic monocarboxylic acid anhydride, a dicarboxylic acid anhydride or a combination thereof. Further improvements in efficiency and reduction in process steps are achieved in a process for producing an esterified cellulose ether which comprises the steps of a) reacting cellulose with an alkaline material to produce alkali cellulose, b) reacting the produced alkali cellulose with one or more etherifying agents and washing the produced cellulose ether to obtain a moist cellulose ether having a water content of at least 10 weight percent, and c) reacting the moist cellulose ether with an aliphatic monocarboxylic acid anhydride and/or a dicarboxylic acid anhydride and with a depolymerizing agent.

Efficient process for preparing an ester of a cellulose ether

A continuous process for preparing an oleogel from ethylcellulose and an oily feed material, wherein the process comprises: (a) feeding ethylcellulose to the feed zone of an extruder, the extruder having a plurality of oil feed ports along its length; (b) feeding at least one oily feed material into at least one of the oil feed ports; (c) mixing the oily feed material with the ethylcellulose to form a substantially homogeneous mixture; (d) cooling the mixture to form an oleogel.

Process for preparing an oleogel

An esterified cellulose ether which comprises (i) aliphatic monovalent acyl groups or (ii) groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOA, and which has a) a viscosity of from 1.2 to 1.8 mPaos, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20&#xb0; C., or b) a viscosity of up to 5 mPa&#xb7;s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20&#xb0; C., or c) a combination of the viscosities of a) and b), is useful for preparing solid dispersions comprising drugs.

Esterified cellulose ethers of very low viscosity

A process for recovering an esterified cellulose ether from a reaction product mixture obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid anhydride or a di- or tricarboxylic acid anhydride or a combination of an aliphatic monocarboxylic acid anhydride and a di- or tricarboxylic acid anhydride, comprises the steps of (i) contacting the reaction product mixture with an aqueous liquid to precipitate the esterified cellulose ether from the reaction product mixture, (ii) isolating the precipitated esterified cellulose ether from the mixture obtained in step (i), and (iii) suspending the isolated esterified cellulose ether in an aqueous liquid to provide a suspension having a temperature of at least 28&#xb0; C., and (iv) recovering the esterified cellulose ether from the suspension of step (iii).

Process for recovering an esterified cellulose ether from a reaction product mixture

A reaction product mixture is obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid anhydride or with a di- or tricarboxylic acid anhydride or with a combination of an aliphatic monocarboxylic acid anhydride and a di- or tricarboxylic acid anhydride in the presence of (c) an aliphatic carboxylic acid. A process for precipitating an esterified cellulose ether from this reaction product mixture comprises the step of contacting the reaction product mixture with water and subjecting the combination of water and the reaction product mixture to a shear rate of at least 800 s. The precipitated esterified cellulose ether can be recovered as a non-tacky product.

Process of preparing an ester of a cellulose ether

A process for making substituted polyethylene glycol compound. The compound has the formula RO(C2H40)nH wherein R represents a C1&#x2013;7 hydrocarbon group and n represents the average number of moles of C2H40 groups, ranging from 500 to 2000. The compound has a ratio of weight average molecular weight to a number average molecular weight in the range of from 1 to 1.1. The compound contains less than ten weight percent polyethylene glycol. The gist of the process is the use of a polyether solvent, wherein the n value of the compound ranges from 600 to 2000.

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Midland, MI, United States of America

Robert B Appell