Roussel Uclaf

Aventis Pharma S.a.

Centre National De La Recherche Scientifique

Robert Azerad

Jacques Biton

Isabelle Lacroix

Jean D'Angelo

Didier Buisson

Gilbert Revial

Francine Acher

Jean Philippe Pin

Jean-Pierre Marchandeau

A process for the preparation of a compound of the formula by means of bioconversion with a microorganism culture of a compound of the formula 

Process for the preparation of Fexofenadine

The invention concerns a method for preparing Fexofenadine from Terfenadine by a bioconversion process using LCP 63-1800 or NRRL 2364 strain.

Compounds consisting in particular of effectors of the central nervous system receptors sensitive excitatory amino acids, preparation and biological applications

A compound of the formula ##STR1## having progestomimetic activity, wherein the substituents are as defined in the specification and compositions of a compound of formula I and an estrogen compound.

1- or 6-hydroxylated steroids

New tetra-alkyl-2,2,5,5-cyclohexanone-4-ol-1-compounds and their sulphonyl derivatives with the general formula: ##STR1## in which: each of R and R', identical or different, represents an alkyl radical (1-5 carbons) and R' represents a hydrogen atom or a radical SO.sub.2 R'' in which R'' represents an alkyl radical (1-5 carbons) or an aryl radical (6-14 carbons), the process and the intermediates for their preparation, as well as their use in the synthesis of cyclopropane lactones of cis structure.

Tetra-alkyl-2,2,5,5-cyclohexanone-4-01-1 compounds and their sulphonyl

##STR1## New tetra-alkyl-2,2,5,5 cyclohexanone-4-ol-1 and their sulfonated derivatives of the general formula (I), wherein R and R', which may be the same or different, represent an alkyl radical (1-5 atoms of carbon) and R' represents a hydrogen atom or a radical SO--R'' wherein R'' represents an alkyl radical (1-5 atoms of carbon) or an aryl radical (6-14 atoms of carbon), their preparation intermediaries and process, as well as their application to the synthesis of cyclopropanic lactones having the cis structure.

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Ris Orangis, France

Robert Azerad