Zeneca Limited

Astra Zeneca U.k. Limited

Mochida Pharmaceutical Co., Ltd.

Robert Antony Holt

Andrew John Blacker

Christopher David Reeve

Stuart Richard Rigby

David Waterson

Andrew G Brewster

John David Pittam

John Crosby

Robert Jeffrey Copeland

A process is provided for the preparation of a compound of formula (1) wherein R and R' represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.

Process for the preparation of dihydroxy esters and derivatives thereof

Production of optically active 2-substituted tetrahydropyran-4-ones

An enzymatic process for preparing amides of Formula I

Enzymatic process for stereoselective preparation of a tertiary acid

Enzymatic process for stereoselective preparation of a tertiary alcohol

Method of preparing an optically active compound of formula, wherein R and R.sup.1 are independently alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, cycloalkyl, aryl, aralkyl, a heterocyclic group or a C.sub.1 -C.sub.4 alkyl-heterocycle, each being optionally substituted, procided that R and R.sup.1 are not identical and * is an optically active chiral center, from the corresponding racemic ester or diol by treating with a hydrolase enzyme.

Chiral synthesis of tertiary alcohols with a hydrolase

Catalyzed enantiomeric selection of 1,2-diols and their cyclization to

Process for microbial reduction producing

Growing community of inventors

Billingham, United Kingdom

Robert Antony Holt