Molecular Engine Laboratories

Molecular Engines Laboratories

Societe Molecular Engines Laboratories

Soci&eacute;t&eacute; Molecular Engines Laboratories a French Soci&eacute;t&eacute; Anonyme

Robert Amson

Adam Telerman

Daniel Cohen

Jean-Michel Lassalle

The invention concerns genes involved in the molecular paths for tumor suppression and/or resistance to viruses, and whereof the cell expression is in particular induced or inhibited during apoptosis and/or tumor suppression.

Genes involved in the molecular paths of tumor suppression and/or resistance to viruses

Mice that are deficient in p53 are found to have memory disorders and/or behavioral disorders such as increased anxiety. A method of using p53-deficient mice to screen compounds for memory restoring activity and/or anti-anxiety activity is described.

Use of animal model deficient in p53 and having memory deficiency and/or behavioral disorders for therapeutic purposes

A compound that inhibits the cellular expression of a nucleotide sequence corresponding to all or part of the presenilin 1 gene, the compound comprising an antisense molecule comprising the antisense of a polynucleotide sequence selected from the group consisting of the entire polynucleotide sequence of the presenilin 1 gene, a fragment of the sequence of the presenilin 1 gene, the promoter or other regulatory sequence of the presenilin 1 gene and a polynucleotide sequence that is at least 90% homologous to the polynucleotide sequence of the presenilin 1 gene is described. Pharmaceuticals containing and methods of inhibiting the presenilin 1 gene using such compound are also described. A compound and method of inhibiting the expression product of the presenilin 1 gene also is described. A method of treating a patient having a condition characterized by excessive cell growth also is described. A method of diagnosing cancer also is described. A method of screening drugs that inhibit the presenilin 1 gene also is described. A compound and pharmaceutical that activates the presenilin 1 gene also is described as is a method of treating diseases associated with cell death.

Compound and methods of inhibiting or stimulating presenilin 1 and related pharmaceuticals and diagnostic agents

Tumor Suppressor Activated Pathway (TSAP) genes and nucleotide sequences therefore as well as vectors and cells containing such nucleotide sequences and various uses therefore are described. The mechanism by which TSAP 3 activates apoptosis also is described. Pharmaceutical compositions and methods for preventing tumorigenesis also is described.

Growing community of inventors

Paris, France

Robert Amson