Oxford Glycosciences (UK) Ltd

Robert Amess

Rajesh Bhikhu Parekh

Sally Barbara Prime

James Alexander Bruce

Albert Edward Platt

Richard Michael Stoney

The present invention provides computer-assisted methods and apparatus for identifying, selecting and characterizing biomolecules in a biological sample. A two-dimensional array is generated by separating biomolecules present in a complex mixture. A computer-readable profile is constructed representing the identity and relative abundance of a plurality of biomolecules detected by imaging the two dimensional array. Computer-mediated comparison of profiles from multiple samples permits automated identification of subsets of biomolecules that satisfy pre-ordained criteria. Identified biomolecules can be automatically isolated from the two dimensional array by a robotic device in accordance with computer-generated instructions. A supported gel suitable for electrophoresis is provided that is bonded to a solid support such that the gel has two-dimensional spatial stability and the solid support is substantially non-interfering with respect to detection of a label, such as a fluorescent label, associated with one or more biomolecules in the gel.

Robotic device for removing selected portions of a polyacrylamide gel

Computer-assisted isolation and characterization of proteins

Computer-assisted methods and apparatus for identification and

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Cumnor, United Kingdom

Robert Amess