Syntex (u.s.a.) Inc.

Robert Alvarez

Gordon H Jones

Michael C Venuti

John J Bruno

Robert Stephen Wilhelm

Bruce H Devens

Jurg R Pfister

Bradley E Loe

Michael G Martin

Ronnie L Chin

Benzo or pyridopyridazinones and pyridazinthiones of the formula ##STR1## wherein: X and Y are nitrogen or carbon, provided that at least one is carbon, and Z is oxygen or sulfur;

Benzopyridazinone and pyridopyridazinone compounds

The present invention relates to optionally substituted pyrido[2,3-d]pyrimidine-2,4(1H,3H)-diones or optionally substituted pyrido[2,3-d]pyrimidine-2(1H,3H)-ones, i.e., compounds of Formula I: ##STR1## wherein: Y is --CH.sub.2 -- or --C(O)--;

Optionally substituted pyrido[2,3-d]pyridine-2,4(1H,3H)-diones and

Compounds according to the formula ##STR1## an optical isomer thereof, or a pharmaceutically acceptable acid addition salt thereof wherein:

(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides,

Compounds according to the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein: n is an integer of 1 to 6;

Method of treating heart failure using

N,N-Di

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Menlo Park, CA, United States of America

Robert Alvarez