Novartis Ag

Robert Alexander Pulz

Nichola Smith

Thomas Josef Troxler

Mahbub Ahmed

Lisa Ann Rooney

Anne-Marie Edwards

Nikolaus Johannes Stiefl

Duncan Shaw

Roger John Taylor

David Andrew Sandham

Kamlesh Jagdis Bala

Catherine LeBlanc

David William Porter

James Dale

Joe Wrigglesworth

Jessica Louise Taylor

Andrew Brearley

Peter Hunt

Claire Adcock

Maude Nadine Pierrette Pipet

Robin Alec Fairhurst

Catherine Leblanc

Urs Baettig

Anna Vulpetti

Katrin Spiegel

Richard Heng

Guido Koch

Anne-Marie D'Souza

Rudolf Waelchli

Elizabeth Kate Hoegenauer

Ann-Marie D'SOUZA

David Porter

Anne-Marie D'souza

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Carboxamide derivatives

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt or co-crystal thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

The present invention describes new pyrrolo pyrimidine derivatives and pharmaceutically acceptable salts thereof which appear to interact with Bruton's tyrosine kinase (Btk). Accordingly, the novel pyrrolo pyrimidines may be effective in the treatment of autoimmune disorders, inflammatory diseases, allergic diseases, airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), transplant rejection, cancers e.g. of hematopoietic origin or solid tumors.

Pyrrolo pyrimidine derivatives

Compounds of formula (I) in free or salt or solvate form, where T, T, and Thave the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described. 

Organic compounds

Compounds of formula I in free or salt or solvate form, where T, T, X, R, R, Rand Rhave the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Compounds of formula I in free or salt or solvate form, wherein X, T, Tand Thave the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Pyrrolopyrimidines and pyrrolopyridines

Compounds of formula (I) in free or salt or solvate form, where T, T, Rand Rhave the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described. 

Pyrimidine derivatives as alk-5 inhibitors

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Basel, Switzerland

Robert Alexander Pulz