Diatech Pty. Ltd.

Adalta Pty Ltd.

Anaptysbio, Inc.

Quintain Consulting Pty Ltd

Robert Alexander Irving

Peter John Hudson

Stewart Douglas Nuttall

Maria Galanis

Gregory Coia

Stewart Nuttal

Peter Iliades

Kylie Anne Henderson

David Peter Simmons

Miles Mackay Barraclough

Joseph Noozhumurry Varghese

Jennifer Ann Carmichael

Katherine Merne Griffiths

Victor Streltsov

Huseyin Mustafa

Kim Wark

Matias Ezequiel Abregu

Joseph Noozhumutry Varghese

The present invention relates to immunoglobulin new antigen receptors (IgNARs) from fish and uses thereof. In particular, the present invention relates to modified IgNAR variable domains and to domains from members of the immunoglobulin superfamily that have been modified to include structural features derived from IgNAR variable domains.

Binding moieties based on shark ignar domains

The present invention relates to binding moieties comprising at least one monomeric V-like domain (VLD) derived from a non-antibody ligand, the at least one monomeric V-like domain being characterised in that at least one CDR loop structure or part thereof is modified or replaced such that the solubility of the modified VLD is improved when compared with the unmodified VLD.

V-like domain binding molecules and polynucleotides encoding therefor

The present invention relates to binding moieties comprising at least one monomeric V-like domain (VLD) derived from a non-antibody ligand, the at least one monomeric V-like domain being characterized in that at least one CDR loop structure or part thereof is modified or replaced such that the solubility of the modified VLD is improved when compared with the unmodified VLD.

V-like domain binding molecules

The present invention provides a method for the mutation, synthesis and selection of a protein which binds to a target molecule, the method comprising: (a) incubating a replicable mRNA molecule encoding the protein with ribonucleoside triphosphate precursors of RNA and an RNA-directed RNA polymerase, wherein the RNA-directed RNA polymerase replicates the mRNA molecule but introduces mutations thereby generating a population of mutant mRNA molecules; (b) incubating the mutant mRNA molecules from step (a) with a translation system under conditions which results in the synthesis of population of mutant proteins such that after translation, mutant proteins are linked to their encoding mRNA molecules thereby forming a population of mutant proteins such that after translation, mutant proteins are linked to their encoding mRNA molecules thereby forming a population of mutant/mRNA complexes; (c) selecting one or more mutant protein/mRNA complex(es) by exposing the population of mutant protein/mRNA complexes from step (b) to the target molecule and recovering the mutant protein/mRNA complex(es) bound thereto.

Continuous in vitro evolution

Growing community of inventors

Mulgrave, Australia

Robert Alexander Irving