Sanofi

The Salk Institute for Biological Studies

Aventis Pharma Deutschland, Gmbh

Robert Alan Binnie

Magda Stankova

Gary A Flynn

Elisabeth Defossa

Hans Ulrich Stilz

Paulus Wohlfart

Armin Walser

Stephanie Hachtel

Jacques Mauger

Fahad A Al-Obeidi

Tony Hunter

John Weston

William Jerome Bock

Marco Mueller

Martin Gerl

Stephen Rush Fuhs

Jill Meisenhelder

Katharina Mertsch

Jian-Hui Weng

Farid Abdul-Latif

A peptide is disclosed of the general structure: Z&#x2014;W&#x2014;Y, wherein Z and Y are independently a one to eight amino acid sequence wherein the amino acids are selected from glycine and alanine and W is a non-hydrolyzable pHis analogue. Such peptides can be used to produce sequence-independent anti-phosphohistidine antibodies. Also provided are antibodies that specifically bind to a peptide comprising a phosphohistidine (or a non-hydrolyzable pHis analogue) but fail to specifically bind to an identical peptide containing histidine instead of phosphohistidine.

Compositions and methods for analyzing histidine phosphorylation

The present invention relates to benzoimidazole-carboxylic acid amide compounds of the formula I, in which R', R&#x2033;, R&#x2032;&#x2033;, R, R, R, R, R, Rand Z are defined as indicated below. The compounds of the formula I are APJ receptor modulators, and are useful for the treatment of diseases associated with increased blood pressure for example. The invention furthermore relates to the use of compounds of the formula I, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

Benzoimidazole-carboxylic acid amide derivatives as APJ receptor modulators

Low molecular weight peptide derivatives which are able to act as inhibitors of the interaction between laminin and nidogen (laminin/nidogen interaction), a process for their preparation, pharmaceutical compositions prepared therefrom and their use for preparing pharmaceuticals and for identifying inhibitors of the laminin/nidogen interaction.

Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction

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Tucson, AZ, United States of America

Robert Alan Binnie