Other

University of Illinois

Robert A Warwick

Kenneth L Rinehart

Dolores Garcia Gravalos

Glynn Thomas Faircloth

Jesus Avila

Nancy L Fregeau Gallagher

Nancy L Fregeau

Nancy L Gallagher

Investigation of the activity of extracts of the clamhas led to antitumor long-chain, straight-chain alkane or alkene compounds which have a 2-amino group and a 3-hydroxy group. The present invention is directed to compositions and methods comprising an isolated and purified long-chain, straight-chain 2-amino-3-hydroxyalkane, or prodrug thereof, and a pharmaceutically acceptable carrier, wherein the carbon chain in the long-chain, straight-chain 2-amino-3-hydroxyalkane is C&#x2013;C.

Compositions and methods comprising long-chain, straight-chain 2-amino-3-hydroxyalkanes

The present invention is directed to the isolation and bioactive characterization of compounds isolated from the clam Spisula polynyma. These compounds include three sphingoid-type bases, spisulosines 285, 299 and 313 (1-3), each of which shows unique cytotoxicity against L1210 murine lymphocytic leukemia cells. In addition, sphingosine (also referred to as 4-sphingenine or octadeca-4-shpingenine, 4) and two related compounds, nonadeca-4-sphingenine (a one carbon longer homolog, 5) and sphinga-4,10-diene (a dehydrosphingosine deravitive, 6) were also obtained, These compounds also contribute to the cytotoxicity of the Spisula polynyma extracts, but did not cause the morphology changes observed with compounds 1-3.

Spisulosine compounds

Investigation of the activity of extracts of the clam has led to antitumour long-chain, straight-chain alkane or alkene compounds which have a 2-amino group and a 3-hydroxy group.

A boat mooring device for being detachably affixed to the side of a pile extending upright in the water and which device has a vertically moveable element attachable to a boat for retaining the boat to the pile, but riding up and down with the boat during changes of tide or waves.

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Urbana, IL, United States of America

Robert A Warwick