Other

Secure Computing Corporation

Alphavax, Incorporated

Sloan-kettering Institute for Cancer Research

Robert A Olmsted

Sergey A Dryga

Thomas R Markham

William E Boebert

Robert E Johnston

Nancy L Davis

Ronald I Swanstrom

Elizabeth A Reap

Ian Caley

Maureen Maughan

Paula M Keith

Jonathan C Rice

Jeffrey D Chulay

John S Morris

Francesca Avogadri

The present invention provides methods and compositions comprising a population of alphavirus replicon particles comprising alphavirus replicon RNAs, wherein a first replicon RNA comprises nucleic acid encoding cytomegalovirus pp65 and IE1 protein or immunogenic fragments thereof, and a second replicon RNA comprises nucleic acid encoding cytomegalovirus gB protein or an immunogenic fragment thereof, and wherein each of the two replicon RNAs is contained within a separate alphavirus replicon particle.

Alpha virus-based cytomegalovirus vaccines

The present invention provides methods and compositions comprising a population of alphavirus replicon particles comprising two or more isolated nucleic acids selected from 1) an isolated nucleic acid encoding an env gene product or an immunogenic fragment thereof of a human immunodeficiency virus, 2) an isolated nucleic acid encoding a g&agr;g gene product or an immunogenic fragment thereof of a human immunodeficiency virus, wherein the g&agr;g gene product or immunogenic fragment thereof is modified to inhibit formation of virus-like particles containing the g&agr;g gene product or the immunogenic fragment thereof and their release from a cell, and 3) an isolated nucleic acid encoding a pol gene product or an immunogenic fragment thereof of a human immunodeficiency virus, wherein the pol gene product or immunogenic fragment thereof is modified to inhibit protease, integrase, RNase H and/or reverse transcriptase activity, and wherein the nucleic acids are each contained within a separate alphavirus replicon particle.

Alphavirus vectors and virosomes with modified HIV genes for use in vaccines

A data communication system providing for the secure transfer and sharing of data via a local area network and/or a wide area network. The system includes a secure processing unit which communicates with a personal keying device and a crypto media controller attached to a user's Workstation. The communication between these processing elements generates a variety of data elements including keys, identifiers, and attributes. The data elements are used to identify and authenticate the user, assign user security access rights and privileges, and assign media and device attributes to a data access device according to a predefined security policy. The data elements are manipulated, combined, protected, and distributed through the network to the appropriate data access devices, which prevents the user from obtaining unauthorized data.

Data enclave and trusted path system

A method and apparatus for controlling model vehicles in a manner which accurately simulates the operation of real vehicles. Parameters relating to operational characteristics of a vehicle, environmental conditions, loading conditions, operator control settings, and physical characteristics of a controllable model are processed by a computer to determine appropriate control functions to a model allowing it to accurately replicate the operation of a real vehicle operating under the same set of conditions.

Method and system for simulating vehicle operation using scale models

Growing community of inventors

Minnetonka, MN, United States of America

Robert A Olmsted