Matritech, Inc.

Monsanto Technology LLC

The Feinstein Institutes for Medical Research

Cornerstone Therapeutics, Inc.

Critical Therapeutics, Inc.

Robert A Obar

Ying-Jye Wu

Susan K Keesee

Walter Newman

Theresa O'Keefe

Shixin Qin

Jeffrey P Cambray

Caroline Slater

Theresa O'keefe

In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to a vertebrate high mobility group box (HMGB) polypeptide, methods of detecting and/or identifying an agent that binds to an HMGB polypeptide, methods of treating a condition in a subject characterized by activation of an inflammatory cytokine cascade and methods of detecting an HMGB polypeptide in a sample.

Monoclonal antibodies against HMGB1

The invention provides a wide range of methods and compositions for detecting and treating cervical cancer in an individual. Specifically, the invention provides target cervical cancer-associated proteins, which permit a rapid detection, preferably before metastases occur, of cervical cancer. The target cervical cancer-associated protein, may be detected, for example, by reacting the sample with a labeled binding moiety, for example, a labeled antibody capable of binding specifically to the protein. The invention also provides kits useful in the detection of cervical cancer in an individual. In addition, the invention provides methods utilizing the cervical cancer-associated proteins either as targets for treating cervical cancer or as indicators for monitoring of the efficacy of such a treatment.

Methods for the detection of cervical cancer

Arrays of polynucleotide or polypeptide target molecules immobilized on a surface of a substrate where the target molecules are arranged in the array according to intensity of organism expression of cognate probe molecules which hybridize to the target molecules. For instance, target molecules having a higher than average indicia of hybridization, e.g. at least a factor of 2, are segregated at a peripheral region of the substrate and at a lower surface density. Preferred arrays can contain animal, plant or microorganism target molecules including . Diagnostic arrays can comprise targets from mixed species, e.g. human, mouse and virus; plant breeding arrays can comprise targets from mixed plants, e.g. , maize, soy, cotton, wheat, rice, canola and potato.

Polymeric arrays adapted for high expressing polynucleotides

Disclosed are proteins indicative of breast cancer and of other cancers, and methods for their detection. Methods of the invention provide an improvement in cancer detection assays, especially in breast cancer detection assays.

Materials and methods for detection of breast cancer

Provided are materials and methods for early diagnosis of breast cancer by detection of breast cancer-associated proteins.

Growing community of inventors

Walpole, MA, United States of America

Robert A Obar