Duke University

University of North Carolina at Chapel Hill

Robert A Nicholas

Eric John Toone

Pei Zhou

Frank Navas, Iii

Ramesh Gopalaswamy

Xiaofei Liang

Frank Iii Navas

Disclosed are compounds of formulae: and pharmaceutically acceptable salts thereof, wherein the variables, R, R, R, R, R, R, R, R, R, R, R, R, R, R, n, and m are defined herein. These compounds are useful for treating Gram-negative bacteria infections. Also disclosed are methods of making these compounds.

Benzoylglycine derivatives and methods of making and using same

Disclosed are compounds of formulae: and pharmaceutically acceptable salts thereof, wherein the variables, R, R, R, R, R, R, R, R, R, R, R, R, R, R, n, and m are defined herein. These compounds are useful for treating Gram-negative bacteria infections. Also disclosed are methods of making these compounds. 

Disclosed are compounds of formulae: (I), and (II) and pharmaceutically acceptable salts thereof, wherein the variables, R, R, R, R, R, R, R, R, R, R, R, D, Q, Y, X, X, X, and Xare defined herein. These compounds are useful for treating Gram-negative bacteria infections. 

Substituted hydroxamic acid compounds

Disclosed are compounds of formulae (I) and (II) and pharmaceutically acceptable salts thereof, wherein the variables, R, R, R, R, Y, Z, X, R, R, R, R, Y, Z, X, and Xare defined herein. These compounds are useful for treating Gram-negative bacteria infections, such asbacterial infections. 

Antibacterial compounds

Disclosed are compounds of formulae: (I) and pharmaceutically acceptable salts thereof, wherein the variables, R, R, Y, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections. 

Growing community of inventors

Chapel Hill, NC, United States of America

Robert A Nicholas