The University of Texas System

Robert A Kirken

Waldemar Priebe

Izabela Fokt

Barry D Kahan

Stanislaw M Stepkowski

Szymon Kosinski

Methods are disclosed for inhibiting or disrupting Janus tyrosine kinase 3 (Jak3) dependent function in cells of lymphoid or myeloid origin, especially for blocking proliferation and function of lymphocytes (e.g., T-cells, B-cells). A Mannich base compound, or a derivative or modified compound, is employed which is capable of selectively inhibiting Jak3 while affecting other protein tyrosine kinase activities to a lesser extent or not at all, to provide beneficial effects such as mitigation of transplant rejection and alleviation of allergic responses with fewer side effects than with conventional immunosuppressive agents.

Growing community of inventors

El Paso, TX, United States of America

Robert A Kirken