Sri International

Robert A Howd

Ralph New Harris, Iii

Clifford D Bedford

Gary A Koolpe

Duane E Hilmas

Richard A Kenley

Dane A Goff

Robert O Pick

A therapeutically effective class of low toxicity aldoxime-substituted functionalized imidazolium compounds and compositions is disclosed which is effective in the treatment of living species poisoned by organophosphorus chemicals which inactivate the enzyme acetylcholinesterase. In vivo administration of therapeutically effective amounts of these aldoxime-substituted imidazolium derivatives has been found to save mammals having inhibited acetylcholinesterase due to injection with lethal dosages of Soman.

Aldoxime-substituted imidazolium derivatives useful in the treatment of

A therapeutically effective class of low toxicity aldoxime-substituted trazolium derivatives is disclosed which is effective in the treatment of living species poisoned by organophosphorus chemicals which inactivate the enzyme acetylcholinesterase. In vivo administration of therapeutically effective amounts of these low toxicity aldoxime-substituted triazolium derivatives has been found to save mice having inhibited acetylcholinesterase due to injection with lethal dosages of Soman.

Aldoxime-substituted triazolium compounds useful in the treatment of

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Rancho Cordova, CA, United States of America

Robert A Howd