Florida State University Research Foundation, Inc.

Fsu Research Foundation, Inc.

Other

Lockheed Martin Corporation

Bristol-myers Squibb Compnay

Research Corporation Technologies, Inc.

Voxx International Corporation

Psu Research Foundation, Inc.

Robert A Holton

Carmen Somoza

Ki-byung Chai

Hossain Nadizadeh

Yukio Suzuki

Mitsuru Shindo

Phong Vu

Chunlin Tao

Feng Liang

Kasthuri Rengan

Hyeong Baik Kim

Ronald J Biediger

Krishna K Murthi

P Douglas Boatman

Chase Smith

Hamid Idmoumaz

Zhuming Zhang

Paul A Clarke

Seokchan Kim

Suhan Tang

Vincent Reboul

Weishuo Fang

Tawfik Gharbaoui

Ronald J Beidiger

Shu-Hui Chen

Vittorio Farina

Mike Morales

Li-Xi Yang

Jonathan Reiblich

David A Huyett

Steve Preston

Richard Lowenthal

Rouh-Rong Juo

Hossain Nabizadeh

Carmon Somoza

A vehicle entertainment system is for use with wireless headphones, with each wireless headphone being operable via a respective paired wireless connection. The vehicle entertainment system may include video entertainment displays for a vehicle, and a controller for the vehicle. The controller may be configured to establish respective paired wireless connections with the wireless headphones, and provide selectable access to a plurality of different audio/video (A/V) entertainment content streams. Each of the A/V entertainment content streams may include a respective video entertainment stream and an associated audio entertainment stream. The controller may be further configured to send selected video entertainment content streams for viewing at the video entertainment displays, and send selected audio entertainment content streams over the respective paired wireless connections for hearing at the wireless headphones.

Vehicle entertainment system providing paired wireless connections for multiple wireless headphones and related methods

The present disclosure relates to a miniature precision clamping assembly driven by a shape memory alloy actuator wire (SMA wire) which may be employed within a braking or clutch system. The clamping assembly includes a first clamping element, a second clamping element and an SMA wire connected to the first and second clamping elements by being interwoven through a plurality of pressure amplifiers located on the exterior surfaces of the first and second clamping elements. Both the first and second clamping elements are configured to be positioned about a rotatable shaft and move in translation to the shaft via a transition action of the SMA wire between a clamping and releasing position. By energizing the SMA wire a contracting or compressing action is generated thereby causing the first and second clamping elements to move into engagement with the one shaft for inhibiting rotational movement.

Clamping assembly employing a shape memory alloy actuating apparatus

Taxanes having an ethyl ester or cyclopropyl ester substituent at C(10), a keto substituent at C(9), a hydroxy substituent at C(7), a thienyl substituent at C(3') and a cyclobutyloxycarbamate or cyclopentyloxycarbamate substituent at C(3&#x2032;), pharmaceutical compositions comprising such taxanes, methods of treatment and administration, and methods of preparation of medicaments comprising the taxanes.

C(10) ethyl ester and C(10) cyclopropyl ester substituted taxanes

A taxane having a cyclopentyl ester substituent at C10, a keto substituent at C9, a hydroxy substituent at C2, a 2-thienyl substituent at C3' and an isopropoxycarbamate substituent at C3&#x2032;.

C10 cyclopentyl ester substituted taxanes

The present invention provides processes for the production of polycyclic fused ring compounds. The polycyclic fused ring compounds are produced by protecting a polycyclic fused ring polyol with a bridging silicon-based protecting group and attaching a suitable side chain. Polycyclic fused ring compounds and intermediate compounds are also described.

Processes for the production of polycyclic fused ring compounds

The present invention provides processes for the production of docetaxel. Docetaxel is produced by protecting the C(7) and the C(10) hydroxy groups of 10-DAB with a bridging silicon-based protecting group. The resulting 7,10-protected 10-DAB derivative is then derivatized and deprotected to form docetaxel.

Processes for the preparation of docetaxel

The present invention is directed to a process for the preparation of &#x3b2;-lactams. Generally, an imine is cyclocondensed with a ketene acetal or enolate to form the &#x3b2;-lactam product in a 'one pot' synthesis, this process is generally performed at a higher temperature than conventional processes.

&#x3b2;-lactam synthesis

Taxanes having an ester substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.

Taxanes having a C10 ester substituent

The present invention provides processes for the production of paclitaxel. Paclitaxel is produced by protecting the C(7) and the C(10) hydroxy groups of 10-DAB with a bridging silicon-based protecting group. The resulting 7,10-protected 10-DAB derivative is then derivatized and deprotected to form paclitaxel.

Processes for the preparation of paclitaxel

Processes for the preparation of taxol and other taxanes through selective derivatization of the C(7) and C(10) hydroxyl groups of 10-DAB, particularly a novel process using a new strategy in which the C(10) hydroxyl group is protected or derivatized prior to the C(7) hydroxyl group; and the provision of C(7) and C(10) derivatized 10-DAB compounds.

Process for selective derivatization of taxanes

Taxanes having a methylcarbonate or ethylcarbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(13) side chain substituents.

Taxanes having a C10 carbonate substituent

Compositions comprising a taxane having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.

C10 carbamoyloxy substituted taxane compositions

Taxanes having a carbonate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.

Taxanes having a C7 carbonate substituent

Taxanes having an ester substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.

C7 ester substituted taxanes

Growing community of inventors

Tallahassee, FL, United States of America

Robert A Holton