Cancer Research Technology Limited

Robert A Heald

Lloyd Royston Kelland

Malcolm F G Stevens

The present invention pertains to certain N,N-disubstituted quino[4,3,2-kl]acridinium salts of formula (Q) which inhibit telomerase wherein: p is an integer from 0 to 4; q is an integer from 0 to 3; r is an integer from 0 to 4; each Ris &#x2014;H or a ring substituent; each Ris &#x2014;H or a ring substituent; each Ris &#x2014;H or a ring substituent; Ris a nitrogen substituent; Ris a nitrogen substituent; and, Q is an anion. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit telomerase, to regulate cell proliferation, and in the treatment of proliferative conditions, such as cancer.

Growing community of inventors

Kettering, United Kingdom

Robert A Heald