Merck + Co., Inc.

Other

Robert A Giacobbe

Deborah L Zink

Robert E Schwartz

Gerald F Bills

Suzanne M Mandala

Otto D Hensens

Fernando Pelaez

Maria T Diez

Jerrold M Liesch

Janet C Onishi

Guy H Harris

Isabel Martin

James E Curotto

Rosemary A Thornton

Angeles Cabello

Sagrario M Del Val

Francisca Vicente

Fernando Pelaez Perez

Angeles Cabello Arroyo

Richard L Monaghan

Seok H Lee

Maria L Garcia

John R Thompson

Michael A Goetz

Owen B McManus

Yu L Kong

E Tracy Jones

Gregory L Helms

Walter Rozdilsky

Maria S Meinz

Isabella Martin

Siobhan Stevens-Miles

Evon A Bolessa

Isabel Martin Fernandez

Teresa Diez Matas

Francisca Vicente Perez

Sheo B Singh

George M Garrity

Louis Kaplan

Gregory J Kaczorowski

Henry Joshua

Prakash S Masurekar

Monty E Vincent

Jon David Polishook

Carol F Wichmann

Michael D Greenspan

Sandra A Morris

Wendy S Horn

Jan S Tkacz

Jonathan N Lipsky

Teresa D Matas

Richard K Jansson

John R Costello, Jr

James A Milligan

Bruce W Burgess

Margaret S Sosa

Mark Rattray

E Tracy Turner Jones

Leeyan Huang

Maria T Matas

S Dreikorn

Ralph W Collins

Wendy H Clapp-Shapiro

Lucia Herranz

Gerard F Bills

Julian Gorrochategui

Robert A Fromtling

Barnali Pramanik

Francisca Vincente Perez

Joan A Lasota

A closure (,) for sealing a micro-organism container (,) is disclosed. The closure (,) includes a resilient seal (,) for sealing the container (,), a passageway (,) extending through the seal (,), or filter media (,) extending across the passageway (,) integrally molded to the seal (,) for allowing sterile gas exchange therethrough. A method of making a flask closure (,) is also disclosed. The method includes molding a sealing member (,) having a port (,) extending therethrough while simultaneously sealing a peripheral edge (,) of a filter media (,) within the passageway (,).

Flask vent and method of making same

There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.

Antifungal agent from sporomiella minimoides

Antifungal agent obtained from hormonema

There is disclosed a compound having the formula ##STR1## which is produced by the fungus, Arthrinium arundinis ATCC 74359, and exhibits antifungal activity.

Antifungal agent produced by arthrinium arundinis  ATCC 74359

Antifungal agent

A compound having the formula ##STR1## which is an anti-fungal agent is described. The producing organism Colletotricum accutatum is also described, along with a method of production.

Anti-fungal agents

The present invention relates to compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof which are useful as potassium channel antagonists, particularly Maxi-K channel antagonists, and thus useful in treating Alzheimer's Disease and other cognitive disorders. This invention is also related to a method of making the compound of formula (I).

Indole diterpene alkaloid compounds

A compound having the formula ##STR1## which is useful as an antifungal agent and for the treatment and control of several agricultural phytopathogens, including Phytophthora infestans, is disclosed.

The present invention relates to novel potassium channel agonists which are useful in activating the calcium activated Maxi-K potassium channel in mammalian neuronal and smooth muscle tissue. The claimed compounds are of the general formula: ##STR1## In addition, a novel microbiological process for producing the claimed compounds is described.

Biologically active compounds

Fermentation processes for the production of a compound of the Structural Formula I ##STR1## The compound of Structural Formula I has been shown to have endothelin antagonist activity and is therefore useful in treating cardiovascular disorders, such as hypertension, congestive heart failure, postischemic renal failure vasospasm, cerebral and cardia ischemia, myocardial infarction inflammatory diseases, Raynaud's disease, endotoxin shock and asthma.

Process for the production of a novel endothelin antagonist

A compound of the formula 1: ##STR1## is produced via fermentation of a fungal isolate ATCC no. 74235. The organism is included herein, as well as a process for production of the compound, a pharmaceutical composition and a method of treatment.

Antifungal compound and compositions containing the compound

Compounds having the formula ##STR1## wherein R and R.sup.1 may be H or COCH.sub.3 provided that when R.sup.1 is COCH.sub.3, R is COCH.sub.3 are described.

Antibiotic agents

Substituted hexahydrobenzopyran derivatives of the Formulae A, B, or C are useful as angiotensin II antagonists: ##STR1##

Substituted hexahydrobenzopyran derivatives as angiotensin II antagonists

Compound of formulae (I) and (II) are HMG-CoA synthase inhibitors and exhibit antifungal activity. ##STR1##

Novel HMG-CoA synthase inhibitors

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Lavallette, NJ, United States of America

Robert A Giacobbe