Eli Lilly and Company

Robert A Conrad

Koert Gerzon

Gerald L Thompson

Gloria C Paschal

George J Cullinan

Jean C Miller

William A White

Amide and ester derivatives of substituted-4(1H)-oxocinnoline-3-carboxylic acids have antibacterial activity and are useful for inhibiting the growth of disease causing bacteria.

4(1H)-Oxocinnoline-3-carboxylic acid derivatives

VLB, 4'-deoxyleurosidine, leurosine and related 1-methyl vinca dimers are oxidized to vincristine-type compounds in tetrahydrofuran solution employing an aqueous chromate-sulfuric acid solution.

Method of preparing vincristine

Bridged vinca dimers in which two indole-dihydro-indole C-3 carboxamides are linked through the nitrogen atom of a carboxamide group, useful as oncolytic agents.

Bridged cathranthus alkaloid dimers

C-3 Carboxamides of leurosine, leuroformine, 4-desacetylleurosine and 4-desacetylleuroformine, useful as antitumor agents.

Amides of leurosine, leuroformine, desacetylleurosine and

5'-Hydroxyleurosine, 5'-hydroxyleuroformine and related compounds, useful in inhibiting the growth of experimental tumors.

Process of producing 5'-hydroxyleurosine and related compounds

5'-Hydroxyleurosine, 5'-hydroxyleuoformine and related compounds, useful in inhibiting the growth of experimental tumors.

Growing community of inventors

Indianapolis, IN, United States of America

Robert A Conrad