Amgen Inc.

Other

Arbor Acres Farm, Inc.

Robert A Bosselman

Krisztina M Zsebo

Francis Hall Martin

Sidney V Suggs

Pamela Hunt

Olaf B Kinstler

Timothy D Bartley

Babru B Samal

Jakob M Bogenberger

Shaw-Fen Sylvia Hu

Murray O Robinson

Margery A Nicolson

Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also disclosed.

SCF antibody compositions and methods of using the same

Method for increasing hematopoietic progenitor cells by stem cell factor

Method of stimulating growth of melanocyte cells by administering stem cell factor

Stem cell factor compositions

Method of preparing human stem cell factor polypeptide

Method for increasing hematopoietic progenitor cells by stem cell factor polypeptides

DNS encoding stem cell factor

DNA encoding stem cell factor

Method for enhancing the effciency of gene transfer with stem cell factor (SCF) polypeptide

Stem cell factor and compositions

Stem cell factor

Disclosed are novel proteins, referred to as megakaryocyte growth and development factors (MGDFs; also generally referred to as Mpl ligands or thrombopoietin, that have a biological activity of stimulating the growth of megakaryocytes and augmenting the differentiation or maturation of megakaryocytes, ultimately to result in the production of platelets. MGDF derivatives comprising MGDF molecules attached to water soluble polymers, such as polyethylene glycol, are also disclosed, along with methods for their preparation. Also disclosed are processes for obtaining the MGDFs in homogeneous form from natural sources and producing them by recombinant genetic engineering techniques from mammals, including humans.

Mono-pegylated proteins that stimulate megakaryocyte growth and

Disclosed are novel proteins, referred to as megakaryocyte growth and development factors (MGDFs; also generally referred to as Mpl ligands), that have a biological activity of stimulating the growth of megakaryocytes and augmenting the differentiation or maturation of megakaryocytes, ultimately to result in the production of platelets. MGDF derivatives comprising MGDF molecules attached to water soluble polymers, such as polyethylene glycol, are also disclosed, along with methods for their preparation. The MGDF proteins and derivatives are useful in methods for treating mammals to increase platelets and/or megakaryocytes. Also disclosed are processes for obtaining the MGDFs in homogeneous form from natural sources and producing them by recombinant genetic engineering techniques from mammals, including humans.

Method for treating mammals with monopegylated proteins that stimulates

Transgenic mice and methods of preparing such mice are disclosed. The mice exhibit decreased platelet counts and/or megakaryocyte leukemia.

Transgenic animal models for thrombocytopenia

A method for introducing a replication-defective retroviral vector into pluripotent stem cells of embryos of an avian species, including chickens, turkeys, quails or ducks. The method is useful for transferring nucleic acid sequences into embryonic avian cells which may differentiate into somatic or germ cells. Transfer into germ cells has been achieved to produce transgenic animals. The replication-defective retroviral vector used for transfer may be a recombinant retroviral vector containing both a retroviral derived nucleic acid sequence and a non-retroviral derived nucleic acid sequence. Examples of non-retroviral nucleic acid sequences are a neomycin resistance gene from the bacterial transposon Tn5, a herpes simplex virus thymidine kinase gene and a chicken growth hormone gene, however, any prokaryotic or eukaryotic nucleic acid sequence of interest may be used. Transgenic chickens have been produced whose cells contain and express a replication-defective retroviral vector nucleic acid sequence.

Method of gene transfer into chickens and other avian species

Growing community of inventors

Thousand Oaks, CA, United States of America

Robert A Bosselman