Sanofi

The Salk Institute for Biological Studies

Robert A Binne

Jacques Mauger

Fahad A Al-Obeidi

Tony Hunter

Magda Stankova

Stephen Rush Fuhs

Jill Meisenhelder

Isolated monoclonal antibodies and or antigen binding fragments thereof are disclosed herein that specifically bind polypeptides comprising a histidine phosphorylated at N3 (3-pHis). Nucleic acids encoding these antibodies, vectors including these nucleic acids, and host cells transformed with these vectors and nucleic acids are also disclosed. Methods are also disclosed for using these antibodies, such as for detection of polypeptides comprising a histidine phosphorylated at N3 (3-pHis). In some embodiments, the methods can be used to investigate signal transduction pathways.

Generation and use of polyclonal and monoclonal antibodies specific for 3-phosphohistidine

Growing community of inventors

Tucson, AZ, United States of America

Robert A Binne