Innocore Technologies B.v.

Polyganics Bv

Innocore Technologies Holding B.v.

Rob Steendam

Theodorus Adrianus Cornelius Flipsen

Catharina Everdina Hissink

Johan Zuidema

Ronald Meyboom

Christine Hiemstra

Hans Wicher Kuijper

Theodorus Adrianus Flipsen

Linda Joan Gibcus

Theodorus Adrianus C Flipsen

Albert Doornbos

Henk Haitjema

Thanh Nguyen

Theodorus Flipsen

The invention is directed to a biodegradable, phase separated, thermoplastic multi-block copolymer, a process for preparing a biodegradable, phase separated, thermoplastic multi-block copolymer, the use of a biodegradable, semi-crystalline, phase separated, thermoplastic multi-block copolymer, and a composition for the delivery of at least one biologically active compound to a host. The multi-block copolymer of the invention comprises at least one amorphous hydrolysable pre-polymer (A) segment and at least one semi-crystalline hydrolysable pre-polymer (B) segment, wherein

Biodegradable, phase separated, thermoplastic multi-block copolymer

This invention is directed to a biodegradable, semi-crystalline, phase separated thermoplastic multi-block copolymer, a process for preparing said multi-block copolymer, a composition for the delivery of at least one biological active compound, and to a method for delivering a biologically active compound to a subject in need thereof. A multi-block copolymer of the invention is characterized in that:

Biodegradable, semi-crystalline, phase separated, thermoplastic multi block copolymers for controlled release of biologically active compounds

The invention is directed to biodegradable, thermoplastic, phase separated segmented multi-block copolymers. The copolymers of the present invention find use in various biomedical applications as well as in pharmaceutical applications. Provided is a composition for the controlled release of at least one biologically active polypeptide to a host, comprising the at least one biologically active polypeptide encapsulated in a matrix comprising at least one phase separated, thermoplastic multi-block copolymer, the copolymer being characterized in that (i) it comprises at least two hydrolysable segments chosen from prepolymer (A) and prepolymer (B), prepolymer (A) having a Tg lower than 37&#xb0; C. and prepolymer (B) having a Tm of 40&#xb0; C.-100&#xb0; C. under physiological conditions; (ii) the segments being linked by a multifunctional chain-extender; (iii) the segments are randomly distributed over the polymer chain; and (iv) prepolymer (A) contains a segment that is derived from a water soluble polymer.

Biodegradable phase separated segmented multi block co-polymers and release of biologically active polypeptides

The invention relates to a biodegradable multi-block copolymer, comprising at least two hydrolysable segments derived from pre-polymers A and B, which segments are linked by a multi-functional chain-extender and are chosen from the pre-polymers A and B, and triblock copolymers ABA and BAB, wherein the multi-block copolymer is amorphous at physiological (body) conditions. The invention further relates to a process for preparing said copolymer and to its use as a medical implant, a coating for a medical device or a drug delivery vehicle.

Biodegradable multi-block co-polymers

The present invention relates to specific DL-lactide-&#x3b5;-caprolactone copolymers and the application of these polymers in the production of biodegradable medical applications. According to the present invention a polymeric material comprising poly(DL-lactide-co-&#x3b5;-caprolactone) is provided, which is obtained by the copolymerization of DL-lactide and &#x3b5;-caprolactone, having a lactide content of 51-75 mol %, most preferably of 62-69 mol %.

DL-lactide-&#x3b5;-caprolactone copolymers

The invention relates, generally, to medical appliances. More particularly, it relates to tubular shaped devices used as drains for draining fluids (liquids and/or gases) from antrums or other parts of the human or animal body. According to the present invention a drain is provided, which is suitable for draining a human or animal antrum, which drain comprises a synthetic biodegradable material, preferably a biodegradable polymer.

Biodegradable drains for medical applications

The present invention relates to specific DL-lactide-&#x3b5;-caprolactone copolymers and the application of these polymers in the production of biodegradable medical applications. According to the present invention a polymeric material comprising poly(DL-lactide-co-&#x3b5;-caprolactone) is provided, which is obtained by the copolymerization of DL-lactide and &#x3b5;-caprolactone, having a lactide content of 51-75 mol %, most preferably of 62-69 mol %. The materials of the present invention have excellent mechanical properties and may be used to provide articles for medical application, in particular nerve guides.

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Groningen, Netherlands

Rob Steendam