Dharmacon, Inc.

Ge Healthcare Dharmacon, Inc.

Elitech Holding B.v.

Elitechgroup B.v.

Rob Kaiser

Anastasia Khvorova

Devin Leake

Christina Yamada

Emily Anderson

Nicolaas M J Vermeulen

Jon Michael Karpilow

Walt Mahoney

Annaleen Vermeulen

Nicolaas Vermeulen

Compositions and methods for inhibiting the actions of non-coding RNAs such as miRNAs and piRNAs are provided. The compositions comprise single or double stranded oligonucleotides conjugated with Minor Groove Binders ('MGBs'). The oligonucleotides can vary in length, can contain nucleotides having one or more modifications, and have regions that are substantially complementary to one or more mature miRNAs or piRNAs.

Minor groove binder (MGB)-oligonucleotide miRNA antagonists

Provided herein are tripartite oligonucleotide complexes which can be administered to a cell, tissue or organism to silence a target gene. The tripartite oligonucleotide complexes of the disclosure may include a conjugate moiety that facilitates delivery to a cell, tissue or organism without the aid of a transfection reagent.

Tripartite oligonucleotide complexes and methods for gene silencing by RNA interference

Provided herein are duplex oligonucleotide complexes which can be administered to a cell, tissue or organism to silence a target gene without the aid of a transfection reagent(s). The duplex oligonucleotide complexes of the disclosure include a conjugate moiety that facilitates delivery to a cell, tissue or organism.

Duplex oligonucleotide complexes and methods for gene silencing by RNA interference

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Broomfield, CO, United States of America

Rob Kaiser