Novartis Vaccines & Diagnostics, Gmbh

Chiron Corporation

Rob Hallewell

Philip J Barr

Dino Dina

Paul A Luciw

Carlos George-Nascimento

Martha Truett

Deborah Lynn Parkes

Kathelyn S Steimer

Ray Sanchez Pescador

Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.

Purified pol DNA, a recombinant DNA construct for expression of HIV pol polypeptide sequences and a cell containing such construct

Method for expressing HIV polypeptides

Recombinant DNA construct for HIV envelope polypeptides and polypeptides produced thereby

Human immunodeficiency virus (HIV) nucleotide sequences

HIV immunoassays using gag polypeptides

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San Francisco, CA, United States of America

Rob Hallewell